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    Cib1 calcium and integrin binding 1 [ Mus musculus (house mouse) ]

    Gene ID: 23991, updated on 3-Apr-2024

    Summary

    Official Symbol
    Cib1provided by MGI
    Official Full Name
    calcium and integrin binding 1provided by MGI
    Primary source
    MGI:MGI:1344418
    See related
    Ensembl:ENSMUSG00000030538 AllianceGenome:MGI:1344418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kip; Cibkip; Prkdcip
    Summary
    Enables protein-membrane adaptor activity and transmembrane transporter binding activity. Involved in several processes, including negative regulation of megakaryocyte differentiation; regulation of intracellular signal transduction; and regulation of protein phosphorylation. Located in cytoplasm and sarcolemma. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human CIB1 (calcium and integrin binding 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in duodenum adult (RPKM 235.6), large intestine adult (RPKM 223.6) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    7 D2; 7 45.55 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (79876904..79882367, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80227156..80232805, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45202 Neighboring gene STARR-positive B cell enhancer ABC_E8182 Neighboring gene STARR-seq mESC enhancer starr_19316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87337544-87337745 Neighboring gene sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B Neighboring gene STARR-seq mESC enhancer starr_19318 Neighboring gene STARR-seq mESC enhancer starr_19319 Neighboring gene STARR-seq mESC enhancer starr_19320 Neighboring gene STARR-seq mESC enhancer starr_19323 Neighboring gene STARR-positive B cell enhancer ABC_E10446 Neighboring gene GDP-D-glucose phosphorylase 1 Neighboring gene STARR-positive B cell enhancer ABC_E4940 Neighboring gene tubulin tyrosine ligase-like family, member 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables calcium-dependent protein kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-membrane adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transmembrane transporter binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to growth factor stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cytoplasmic microtubule organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endomitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of megakaryocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in platelet formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of calcineurin-NFAT signaling cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of calcineurin-NFAT signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of catalytic activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell-matrix adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of male germ cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ischemia IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in thrombopoietin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium and integrin-binding protein 1
    Names
    CIB
    DNA-PKcs-interacting protein
    calcium and integrin binding, protein kinase interacting protein
    calmyrin
    kinase-interacting protein
    protein kinase, DNA activated, catalytic polypeptide interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291275.2NP_001278204.1  calcium and integrin-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001278204.1

      Status: VALIDATED

      Source sequence(s)
      AC109232
      Consensus CDS
      CCDS85324.1
      UniProtKB/TrEMBL
      A0A0U1RPF3
      Related
      ENSMUSP00000145961.2, ENSMUST00000206084.2
      Conserved Domains (2) summary
      cd00051
      Location:106173
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:104172
      EF-hand_7; EF-hand domain pair
    2. NM_001291276.2NP_001278205.1  calcium and integrin-binding protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001278205.1

      Status: VALIDATED

      Source sequence(s)
      AC109232
      Consensus CDS
      CCDS80740.1
      UniProtKB/TrEMBL
      Q8C2K4
      Related
      ENSMUSP00000071401.6, ENSMUST00000071457.12
      Conserved Domains (2) summary
      cd00051
      Location:63130
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
      pfam13499
      Location:61129
      EF-hand_7; EF-hand domain pair
    3. NM_001421973.1NP_001408902.1  calcium and integrin-binding protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC109232
    4. NM_001421974.1NP_001408903.1  calcium and integrin-binding protein 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC109232
    5. NM_001421975.1NP_001408904.1  calcium and integrin-binding protein 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC109232
    6. NM_001421976.1NP_001408905.1  calcium and integrin-binding protein 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC109232
    7. NM_001421977.1NP_001408906.1  calcium and integrin-binding protein 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC109232
    8. NM_001421978.1NP_001408907.1  calcium and integrin-binding protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC109232
    9. NM_001421979.1NP_001408908.1  calcium and integrin-binding protein 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC109232
    10. NM_001421980.1NP_001408909.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    11. NM_001421981.1NP_001408910.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    12. NM_001421982.1NP_001408911.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    13. NM_001421983.1NP_001408912.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    14. NM_001421984.1NP_001408913.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    15. NM_001421985.1NP_001408914.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    16. NM_001421986.1NP_001408915.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    17. NM_001421987.1NP_001408916.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    18. NM_001421988.1NP_001408917.1  calcium and integrin-binding protein 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC109232
    19. NM_011870.6NP_036000.1  calcium and integrin-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_036000.1

      Status: VALIDATED

      Source sequence(s)
      AC109232
      Consensus CDS
      CCDS21392.1
      UniProtKB/Swiss-Prot
      Q3TN80, Q9Z0F4
      Related
      ENSMUSP00000070901.9, ENSMUST00000065163.15
      Conserved Domains (1) summary
      cd00051
      Location:111178
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RNA

    1. NR_185473.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109232
    2. NR_185474.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109232
    3. NR_185475.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC109232

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      79876904..79882367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)