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    Pacsin2 protein kinase C and casein kinase substrate in neurons 2 [ Mus musculus (house mouse) ]

    Gene ID: 23970, updated on 9-Sep-2018

    Summary

    Official Symbol
    Pacsin2provided by MGI
    Official Full Name
    protein kinase C and casein kinase substrate in neurons 2provided by MGI
    Primary source
    MGI:MGI:1345153
    See related
    Ensembl:ENSMUSG00000016664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI197433
    Expression
    Ubiquitous expression in heart adult (RPKM 34.6), kidney adult (RPKM 33.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Pacsin2 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (83375607..83464606, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (83206037..83295036, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor GTPase activating protein 3 Neighboring gene RIKEN cDNA 1700001L05 gene Neighboring gene predicted gene, 41368 Neighboring gene vitamin K epoxide reductase complex, subunit 1-like 1 pseudogene 1 Neighboring gene tubulin tyrosine ligase-like 1 Neighboring gene predicted gene, 46495 Neighboring gene BCL2-interacting killer

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytoskeletal protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeletal protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    lipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphatidic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    caveola assembly ISO
    Inferred from Sequence Orthology
    more info
     
    caveolin-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    modulation of chemical synaptic transmission IDA
    Inferred from Direct Assay
    more info
    PubMed 
    modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane tubulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane tubulation ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to endosome ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    caveola ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endosome IEA
    Inferred from Electronic Annotation
    more info
     
    extrinsic component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    recycling endosome membrane ISO
    Inferred from Sequence Orthology
    more info
     
    NOT trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein kinase C and casein kinase substrate in neurons protein 2
    Names
    Syndapin II
    syndapin-2
    syndapin-II

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159509.1NP_001152981.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001152981.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK083414, BB014072, CA560112, CF168957, CJ118256
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7, Q8BNK9
      Related
      ENSMUSP00000131504.1, ENSMUST00000171436.7
      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:336422
      NPF; Rabosyn-5 repeating NPF sequence-motif
    2. NM_001159510.1NP_001152982.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001152982.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK083414, BB014072, BB860324, BY235086, CA560112, CF168957
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7, Q8BNK9
      Related
      ENSMUSP00000155334.1, ENSMUST00000231184.1
      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:336422
      NPF; Rabosyn-5 repeating NPF sequence-motif
    3. NM_001358641.1NP_001345570.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains a distinct 5' UTR and contains an alternate exon in the coding region, compared to variant 1. The resulting isoform (2) is longer, compared to isoform 1.
      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:350430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    4. NM_001358642.1NP_001345571.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains a distinct 5' UTR and lacks an in-frame portion of the coding region, compared to variant 1. The resulting isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:390445
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    5. NM_001358643.1NP_001345572.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) contains a distinct 5' UTR and lacks an in-frame portion of the coding region, compared to variant 1. The resulting isoform (4) is shorter, compared to isoform 1.
      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:388443
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    6. NM_001358644.1NP_001345573.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) contains a distinct 5' UTR and lacks an in-frame portion of the coding region, compared to variant 1. The resulting isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AC165945, AL583889
      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:390445
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    7. NM_011862.3NP_035992.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform 1

      See identical proteins and their annotated locations for NP_035992.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
      Source sequence(s)
      AK083414, BB014072, BY235086, CA560112, CF168957
      Consensus CDS
      CCDS27701.1
      UniProtKB/Swiss-Prot
      Q9WVE8
      UniProtKB/TrEMBL
      Q3TDA7, Q8BNK9
      Related
      ENSMUSP00000130098.1, ENSMUST00000165095.8
      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:429484
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:336422
      NPF; Rabosyn-5 repeating NPF sequence-motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      83375607..83464606 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520984.1XP_006521047.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X2

      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:390445
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    2. XM_006520979.1XP_006521042.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:350430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    3. XM_011245633.2XP_011243935.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011243935.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:350430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    4. XM_017316605.1XP_017172094.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X2

      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:390445
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
    5. XM_006520981.3XP_006521044.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521044.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:350430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    6. XM_006520980.3XP_006521043.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521043.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:350430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    7. XM_006520983.3XP_006521046.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521046.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:350430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    8. XM_006520982.1XP_006521045.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006521045.1

      Conserved Domains (3) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:431486
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
      pfam16601
      Location:350430
      NPF; Rabosyn-5 repeating NPF sequence-motif
    9. XM_006520985.2XP_006521048.1  protein kinase C and casein kinase substrate in neurons protein 2 isoform X3

      Conserved Domains (2) summary
      cd07679
      Location:18275
      F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)
      cd11998
      Location:388443
      SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
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