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    Dip2b disco interacting protein 2 homolog B [ Mus musculus (house mouse) ]

    Gene ID: 239667, updated on 8-Aug-2021

    Summary

    Official Symbol
    Dip2bprovided by MGI
    Official Full Name
    disco interacting protein 2 homolog Bprovided by MGI
    Primary source
    MGI:MGI:2145977
    See related
    Ensembl:ENSMUSG00000023026
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI317237; AI854602; mKIAA1463; 4932422C22
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 10.4), whole brain E14.5 (RPKM 8.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dip2b in Genome Data Viewer
    Location:
    15; 15 F1
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99935119..100117355)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (100037626..100219474)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99869095..100049904)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 186, member A Neighboring gene predicted gene, 21917 Neighboring gene RIKEN cDNA 2310068J16 gene Neighboring gene La ribonucleoprotein domain family, member 4 Neighboring gene activating transcription factor 1 Neighboring gene transmembrane (C-terminal) protease, serine 12

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1463

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perikaryon IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disco-interacting protein 2 homolog B
    Names
    DIP2 disco-interacting protein 2 homolog B
    DIP2 homolog B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159361.2NP_001152833.1  disco-interacting protein 2 homolog B isoform 1

      See identical proteins and their annotated locations for NP_001152833.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC124479, AC125526, AC133868
      Consensus CDS
      CCDS49731.1
      UniProtKB/Swiss-Prot
      Q3UH60
      Related
      ENSMUSP00000097777.4, ENSMUST00000100203.10
      Conserved Domains (4) summary
      COG0318
      Location:334910
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      pfam00501
      Location:9931468
      AMP-binding; AMP-binding enzyme
      pfam06464
      Location:14130
      DMAP_binding; DMAP1-binding Domain
      cl17068
      Location:358922
      AFD_class_I; Adenylate forming domain, Class I superfamily
    2. NM_172819.3NP_766407.2  disco-interacting protein 2 homolog B isoform 2

      See identical proteins and their annotated locations for NP_766407.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC124479, AC125526
      Consensus CDS
      CCDS27831.1
      UniProtKB/TrEMBL
      B2RQC7
      Related
      ENSMUSP00000023768.8, ENSMUST00000023768.14
      Conserved Domains (3) summary
      COG0318
      Location:100676
      CaiC; Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II [Lipid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism]
      pfam00501
      Location:7591234
      AMP-binding; AMP-binding enzyme
      cl17068
      Location:124688
      AFD_class_I; Adenylate forming domain, Class I superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99935119..100117355
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245629.4XP_011243931.1  disco-interacting protein 2 homolog B isoform X1

      Conserved Domains (2) summary
      cd05905
      Location:10501615
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14130
      DMAP_binding; DMAP1-binding Domain
    2. XM_011245630.4XP_011243932.1  disco-interacting protein 2 homolog B isoform X2

      Conserved Domains (2) summary
      cd05905
      Location:10491614
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14130
      DMAP_binding; DMAP1-binding Domain
    3. XM_006520976.5XP_006521039.1  disco-interacting protein 2 homolog B isoform X3

      Conserved Domains (2) summary
      cd05905
      Location:10041569
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14130
      DMAP_binding; DMAP1-binding Domain
    4. XM_011245631.4XP_011243933.1  disco-interacting protein 2 homolog B isoform X4

      Conserved Domains (2) summary
      cd05905
      Location:9791544
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14130
      DMAP_binding; DMAP1-binding Domain
    5. XM_011245632.4XP_011243934.1  disco-interacting protein 2 homolog B isoform X5

      Conserved Domains (2) summary
      cd05905
      Location:9781543
      Dip2; Disco-interacting protein 2 (Dip2)
      pfam06464
      Location:14130
      DMAP_binding; DMAP1-binding Domain
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