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    A4galt alpha 1,4-galactosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 239559, updated on 31-Jan-2019

    Summary

    Official Symbol
    A4galtprovided by MGI
    Official Full Name
    alpha 1,4-galactosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:3512453
    See related
    Ensembl:ENSMUSG00000047878
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]
    Expression
    Biased expression in ovary adult (RPKM 35.6), bladder adult (RPKM 35.2) and 14 other tissues See more
    Orthologs

    Genomic context

    See A4galt in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (83226722..83251774, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (83057152..83082204, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene RNA U12, small nuclear Neighboring gene cytochrome b5 reductase 3 Neighboring gene predicted gene, 41367 Neighboring gene predicted gene, 32886

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    galactosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    lactosylceramide 4-alpha-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lactosylceramide 4-alpha-galactosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    toxic substance binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity, transferring glycosyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    globoside biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    globoside biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    lactosylceramide 4-alpha-galactosyltransferase
    Names
    Gb3 synthase
    Gb3/CD77 synthase
    UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase
    alpha-1,4-N-acetylglucosaminyltransferase
    alpha4Gal-T1
    globotriaosylceramide synthase
    NP_001004150.1
    NP_001164425.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004150.3NP_001004150.1  lactosylceramide 4-alpha-galactosyltransferase

      See identical proteins and their annotated locations for NP_001004150.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK139833, AY371179
      Consensus CDS
      CCDS27699.1
      UniProtKB/Swiss-Prot
      Q67BJ4
      UniProtKB/TrEMBL
      Q3UF00
      Related
      ENSMUSP00000057999.6, ENSMUST00000049530.13
      Conserved Domains (2) summary
      pfam04488
      Location:100220
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:233355
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
    2. NM_001170954.1NP_001164425.1  lactosylceramide 4-alpha-galactosyltransferase

      See identical proteins and their annotated locations for NP_001164425.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK162529, AY371179, BY770781
      Consensus CDS
      CCDS27699.1
      UniProtKB/Swiss-Prot
      Q67BJ4
      UniProtKB/TrEMBL
      Q3TRS1, Q3UF00
      Related
      ENSMUSP00000129719.1, ENSMUST00000164614.2
      Conserved Domains (2) summary
      pfam04488
      Location:100220
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
      pfam04572
      Location:233355
      Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      83226722..83251774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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