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    Dnajb6 DnaJ heat shock protein family (Hsp40) member B6 [ Mus musculus (house mouse) ]

    Gene ID: 23950, updated on 22-Aug-2021

    Summary

    Official Symbol
    Dnajb6provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B6provided by MGI
    Primary source
    MGI:MGI:1344381
    See related
    Ensembl:ENSMUSG00000029131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mr; Mrj; mDj4; HSJ-2
    Expression
    Ubiquitous expression in testis adult (RPKM 42.9), CNS E18 (RPKM 23.9) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dnajb6 in Genome Data Viewer
    Location:
    5; 5 B1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (29940896..29991476)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (29735898..29786478)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (30062438..30113018)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42245 Neighboring gene predicted gene 43117 Neighboring gene predicted gene 5129 Neighboring gene diamine acetyltransferase 1-like Neighboring gene protein phosphatase 1, regulatory subunit 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102124

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein folding chaperone ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within chorio-allantoic fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within chorion development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intermediate filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within syncytiotrophoblast cell differentiation involved in labyrinthine layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 6
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 6
    heat shock protein J2
    mammalian relative of DnaJ

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037940.4NP_001033029.1  dnaJ homolog subfamily B member 6 isoform a

      See identical proteins and their annotated locations for NP_001033029.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AK032039, AK153091, CJ079100
      Consensus CDS
      CCDS19151.1
      UniProtKB/Swiss-Prot
      O54946
      Related
      ENSMUSP00000008733.9, ENSMUST00000008733.15
      Conserved Domains (2) summary
      COG0484
      Location:2138
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
    2. NM_001037941.3NP_001033030.2  dnaJ homolog subfamily B member 6 isoform b

      See identical proteins and their annotated locations for NP_001033030.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR when compared to variant 1. Variant 2 encodes isoform b, which has a shorter, distinct C-terminus when compared to isoform a.
      Source sequence(s)
      BF660899, CJ079100, DV660970
      Consensus CDS
      CCDS19152.1
      UniProtKB/TrEMBL
      G3X8S5
      Related
      ENSMUSP00000012734.6, ENSMUST00000012734.10
      Conserved Domains (2) summary
      COG0484
      Location:2107
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
    3. NM_001127367.1NP_001120839.1  dnaJ homolog subfamily B member 6 isoform d

      See identical proteins and their annotated locations for NP_001120839.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 3' coding region and 3' UTR when compared to variant 1. Variant 4 encodes isoform d, which has a shorter, distinct C-terminus when compared to isoform a.
      Source sequence(s)
      AK134387, BG800394, CJ079100
      UniProtKB/Swiss-Prot
      O54946
      Conserved Domains (1) summary
      pfam00226
      Location:366
      DnaJ; DnaJ domain
    4. NM_001359198.1NP_001346127.1  dnaJ homolog subfamily B member 6 isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (e) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC122782
      Conserved Domains (1) summary
      cl28246
      Location:3138
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    5. NM_001378835.1NP_001365764.1  dnaJ homolog subfamily B member 6 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC122782
      Conserved Domains (1) summary
      COG0484
      Location:2138
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    6. NM_011847.4NP_035977.2  dnaJ homolog subfamily B member 6 isoform c

      See identical proteins and their annotated locations for NP_035977.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR when compared to variant 1. Variant 3 encodes isoform c, which has a shorter, distinct C-terminus when compared to isoform a.
      Source sequence(s)
      AK134387, CJ079100
      Consensus CDS
      CCDS39043.1
      UniProtKB/Swiss-Prot
      O54946
      Related
      ENSMUSP00000110488.2, ENSMUST00000114839.8
      Conserved Domains (1) summary
      pfam00226
      Location:366
      DnaJ; DnaJ domain

    RNA

    1. NR_152863.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC122782

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      29940896..29991476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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