Format

Send to:

Choose Destination
    • Showing Current items.

    Rspo2 R-spondin 2 [ Mus musculus (house mouse) ]

    Gene ID: 239405, updated on 13-Jul-2021

    Summary

    Official Symbol
    Rspo2provided by MGI
    Official Full Name
    R-spondin 2provided by MGI
    Primary source
    MGI:MGI:1922667
    See related
    Ensembl:ENSMUSG00000051920
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ft; ftls; AA673245; D430027K22; 2610028F08Rik
    Expression
    Biased expression in CNS E11.5 (RPKM 3.5), CNS E18 (RPKM 1.5) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rspo2 in Genome Data Viewer
    Location:
    15 B3.1; 15 16.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (42884184..43034990, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (43020788..43171594, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (42852341..43002364, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41314 Neighboring gene predicted gene, 46505 Neighboring gene predicted gene, 41315 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene eukaryotic translation initiation factor 3, subunit E

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bone mineralization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic forelimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb development ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lung growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within negative regulation of odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within osteoblast differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within trachea cartilage morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    R-spondin-2
    Names
    R-spondin 2 homolog
    cristin-2
    cysteine-rich and single thrombospondin domain-containing protein 2
    mCristin-2
    roof plate-specific spondin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357956.1NP_001344885.1  R-spondin-2 isoform 2 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC121609, AC161450
      Consensus CDS
      CCDS27451.1
      Related
      ENSMUSP00000154600.2, ENSMUST00000226810.2
      Conserved Domains (1) summary
      pfam15913
      Location:40144
      Furin-like_2; Furin-like repeat, cysteine-rich
    2. NM_001357957.1NP_001344886.1  R-spondin-2 isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC121609, AC161450
      Conserved Domains (1) summary
      pfam15913
      Location:47151
      Furin-like_2; Furin-like repeat, cysteine-rich
    3. NM_172815.3NP_766403.1  R-spondin-2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_766403.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC121609, AC161450
      Consensus CDS
      CCDS27451.1
      UniProtKB/Swiss-Prot
      Q8BFU0
      Related
      ENSMUSP00000067325.7, ENSMUST00000063492.8
      Conserved Domains (1) summary
      pfam15913
      Location:40144
      Furin-like_2; Furin-like repeat, cysteine-rich

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      42884184..43034990 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011245607.2XP_011243909.1  R-spondin-2 isoform X5

      See identical proteins and their annotated locations for XP_011243909.1

      Conserved Domains (1) summary
      pfam15913
      Location:47151
      Furin-like_2; Furin-like repeat, cysteine-rich
    2. XM_017316596.3XP_017172085.2  R-spondin-2 isoform X4

      Conserved Domains (2) summary
      pfam15913
      Location:40141
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:144197
      TSP1_spondin; Spondin-like TSP1 domain
    3. XM_011245609.3XP_011243911.2  R-spondin-2 isoform X2

      Conserved Domains (2) summary
      pfam15913
      Location:47148
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:151204
      TSP1_spondin; Spondin-like TSP1 domain
    4. XM_030248538.2XP_030104398.2  R-spondin-2 isoform X4

      Conserved Domains (2) summary
      pfam15913
      Location:40141
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:144197
      TSP1_spondin; Spondin-like TSP1 domain
    5. XM_036159394.1XP_036015287.1  R-spondin-2 isoform X3

      Conserved Domains (2) summary
      pfam15913
      Location:40141
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:145198
      TSP1_spondin; Spondin-like TSP1 domain
    6. XM_036159393.1XP_036015286.1  R-spondin-2 isoform X1

      Conserved Domains (2) summary
      pfam15913
      Location:47148
      Furin-like_2; Furin-like repeat, cysteine-rich
      pfam19028
      Location:152205
      TSP1_spondin; Spondin-like TSP1 domain
    Support Center