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    Katna1 katanin p60 (ATPase-containing) subunit A1 [ Mus musculus (house mouse) ]

    Gene ID: 23924, updated on 3-Feb-2019

    Summary

    Official Symbol
    Katna1provided by MGI
    Official Full Name
    katanin p60 (ATPase-containing) subunit A1provided by MGI
    Primary source
    MGI:MGI:1344353
    See related
    Ensembl:ENSMUSG00000019794
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 6.5), placenta adult (RPKM 5.6) and 27 other tissues See more
    Orthologs

    Genomic context

    See Katna1 in Genome Data Viewer
    Location:
    10; 10 A1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (7726000..7763150)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (7445798..7482948)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Neighboring gene large tumor suppressor Neighboring gene glycoprotein integral membrane 1 Neighboring gene RIKEN cDNA 6530403G13 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dynein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    microtubule-severing ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule-severing ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasmic microtubule organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasmic microtubule organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule bundle formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    microtubule severing IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    microtubule severing ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein localization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone ISO
    Inferred from Sequence Orthology
    more info
     
    lipid droplet IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic spindle pole ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    katanin p60 ATPase-containing subunit A1
    Names
    katanin p60 subunit A1
    lipotransin
    p60 katanin
    NP_035965.2
    XP_006512801.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011835.2NP_035965.2  katanin p60 ATPase-containing subunit A1

      Status: VALIDATED

      Source sequence(s)
      AK012319, AK041900, AV135581
      Consensus CDS
      CCDS23689.2
      UniProtKB/TrEMBL
      E9PZI6
      Related
      ENSMUSP00000132514.1, ENSMUST00000165806.7
      Conserved Domains (3) summary
      smart00382
      Location:243384
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:247383
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:458491
      Vps4_C; Vps4 C terminal oligomerization domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

      Range
      7726000..7763150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512738.2XP_006512801.1  katanin p60 ATPase-containing subunit A1 isoform X1

      Conserved Domains (3) summary
      smart00382
      Location:13154
      AAA; ATPases associated with a variety of cellular activities
      pfam00004
      Location:17153
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam09336
      Location:228261
      Vps4_C; Vps4 C terminal oligomerization domain
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