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    Hs2st1 heparan sulfate 2-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 23908, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hs2st1provided by MGI
    Official Full Name
    heparan sulfate 2-O-sulfotransferase 1provided by MGI
    Primary source
    MGI:MGI:1346049
    See related
    Ensembl:ENSMUSG00000040151 AllianceGenome:MGI:1346049
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2OST; Hs2st; mKIAA0448
    Summary
    Enables heparan sulfate 2-O-sulfotransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Acts upstream of or within several processes, including heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process; heparin metabolic process; and ureteric bud formation. Is active in Golgi apparatus. Is expressed in brain and future brain. Orthologous to human HS2ST1 (heparan sulfate 2-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 8.3), whole brain E14.5 (RPKM 6.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hs2st1 in Genome Data Viewer
    Location:
    3 H2; 3 68.89 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144135462..144275977, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144429701..144570216, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09177 Neighboring gene predicted gene, 54186 Neighboring gene STARR-seq mESC enhancer starr_09178 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr3:144193966-144194266 Neighboring gene predicted gene 43560 Neighboring gene STARR-seq mESC enhancer starr_09180 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:144211269-144211545 Neighboring gene predicted gene, 46829 Neighboring gene STARR-seq mESC enhancer starr_09181 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:144233322-144233673 Neighboring gene selenoprotein F Neighboring gene STARR-seq mESC enhancer starr_09182 Neighboring gene ribosomal protein L9, pseudogene 8

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables heparan sulfate 2-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heparan sulfate 2-O-sulfotransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparan sulfate 2-O-sulfotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables heparan sulfate 2-O-sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    heparan sulfate 2-O-sulfotransferase 1
    Names
    2-O-sulfotransferase
    NP_001342163.1
    NP_035958.3
    XP_006501513.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355234.1NP_001342163.1  heparan sulfate 2-O-sulfotransferase 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC123880, AC159976, BC059008
      Conserved Domains (1) summary
      pfam03567
      Location:76327
      Sulfotransfer_2; Sulfotransferase family
    2. NM_011828.4NP_035958.3  heparan sulfate 2-O-sulfotransferase 1 isoform 2

      See identical proteins and their annotated locations for NP_035958.3

      Status: VALIDATED

      Source sequence(s)
      AC123880, AC159976, BC059008
      Consensus CDS
      CCDS17883.1
      UniProtKB/Swiss-Prot
      O88464, Q3TNP7, Q8R3H7, Q9JLK2
      Related
      ENSMUSP00000043066.8, ENSMUST00000043325.9
      Conserved Domains (1) summary
      pfam03567
      Location:76326
      Sulfotransfer_2; Sulfotransferase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      144135462..144275977 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501450.5XP_006501513.1  heparan sulfate 2-O-sulfotransferase 1 isoform X1

      Conserved Domains (1) summary
      pfam03567
      Location:18269
      Sulfotransfer_2; Sulfotransferase family