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    Grem2 gremlin 2, DAN family BMP antagonist [ Mus musculus (house mouse) ]

    Gene ID: 23893, updated on 29-Jul-2018

    Summary

    Official Symbol
    Grem2provided by MGI
    Official Full Name
    gremlin 2, DAN family BMP antagonistprovided by MGI
    Primary source
    MGI:MGI:1344367
    See related
    Ensembl:ENSMUSG00000050069 Vega:OTTMUSG00000022494
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prdc; Gremlin2
    Expression
    Broad expression in ovary adult (RPKM 15.0), lung adult (RPKM 14.2) and 20 other tissues See more
    Orthologs

    Genomic context

    See Grem2 in Genome Data Viewer
    Location:
    1; 1 H3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (174833785..174921915, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (176763916..176851950, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene olfactory receptor 220 Neighboring gene formin 2 Neighboring gene lines homolog 2 pseudogene Neighboring gene regulator of G protein signaling 7 Neighboring gene fumarate hydratase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    BMP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of dorsal identity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic body morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cytokine activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    sequestering of BMP from receptor via BMP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    gremlin-2
    Names
    Gremlin1
    cysteine knot superfamily 1, BMP antagonist 2
    gremlin 2 homolog, cysteine knot superfamily
    protein related to DAN and cerberus

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011825.1NP_035955.1  gremlin-2 precursor

      See identical proteins and their annotated locations for NP_035955.1

      Status: VALIDATED

      Source sequence(s)
      AB011030
      Consensus CDS
      CCDS15545.1
      UniProtKB/Swiss-Prot
      O88273
      UniProtKB/TrEMBL
      Q3TST1
      Related
      ENSMUSP00000049640.3, OTTMUSP00000025626, ENSMUST00000055294.3, OTTMUST00000053848
      Conserved Domains (1) summary
      pfam03045
      Location:54158
      DAN; DAN domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      174833785..174921915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496826.3XP_006496889.1  gremlin-2 isoform X1

      See identical proteins and their annotated locations for XP_006496889.1

      UniProtKB/Swiss-Prot
      O88273
      UniProtKB/TrEMBL
      Q3TST1
      Conserved Domains (1) summary
      pfam03045
      Location:54158
      DAN; DAN domain
    2. XM_017320448.1XP_017175937.1  gremlin-2 isoform X1

      UniProtKB/Swiss-Prot
      O88273
      UniProtKB/TrEMBL
      Q3TST1
      Conserved Domains (1) summary
      pfam03045
      Location:54158
      DAN; DAN domain
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