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    Ppwd1 peptidylprolyl isomerase domain and WD repeat containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 238831, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ppwd1provided by MGI
    Official Full Name
    peptidylprolyl isomerase domain and WD repeat containing 1provided by MGI
    Primary source
    MGI:MGI:2443069
    See related
    Ensembl:ENSMUSG00000021713
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4632422M10Rik; A330090G21Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 6.8), liver E14 (RPKM 4.5) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Ppwd1 in Genome Data Viewer
    Location:
    13; 13 D1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (104340102..104365378, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (104203594..104228844, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (104995201..105018924, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex 13 Neighboring gene tripartite motif-containing 23 Neighboring gene shieldin complex subunit 3 Neighboring gene centromere protein K Neighboring gene a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 6 Neighboring gene predicted gene 8680 Neighboring gene predicted gene, 53810 Neighboring gene CWC27 spliceosome-associated protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cyclosporin A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein peptidyl-prolyl isomerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein peptidyl-prolyl isomerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    peptidylprolyl isomerase domain and WD repeat-containing protein 1
    NP_766395.2
    XP_011242960.1
    XP_017171002.1
    XP_017171003.1
    XP_017171004.1
    XP_036013937.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172807.4NP_766395.2  peptidylprolyl isomerase domain and WD repeat-containing protein 1

      See identical proteins and their annotated locations for NP_766395.2

      Status: VALIDATED

      Source sequence(s)
      AC154216, AK028532, AK043316
      Consensus CDS
      CCDS26748.1
      UniProtKB/Swiss-Prot
      Q8CEC6
      UniProtKB/TrEMBL
      Q8C908
      Related
      ENSMUSP00000022226.5, ENSMUST00000022226.6
      Conserved Domains (4) summary
      COG2319
      Location:89311
      WD40; WD40 repeat [General function prediction only]
      cd01927
      Location:495643
      cyclophilin_WD40; cyclophilin_WD40: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. ...
      sd00039
      Location:136177
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:89318
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      104340102..104365378 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244658.3XP_011242960.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X4

      Conserved Domains (4) summary
      COG2319
      Location:19176
      WD40; WD40 repeat [General function prediction only]
      cd01927
      Location:355503
      cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
      sd00039
      Location:3981
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:125252
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_017315515.3XP_017171004.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X3

      Conserved Domains (1) summary
      cd01927
      Location:172320
      cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
    3. XM_017315514.3XP_017171003.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X3

      Conserved Domains (1) summary
      cd01927
      Location:172320
      cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
    4. XM_036158044.1XP_036013937.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X1

      Conserved Domains (3) summary
      cd01927
      Location:414562
      cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
      sd00039
      Location:5596
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:8237
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_017315513.2XP_017171002.1  peptidylprolyl isomerase domain and WD repeat-containing protein 1 isoform X2

      Conserved Domains (4) summary
      COG2319
      Location:39160
      WD40; WD40 repeat [General function prediction only]
      cd01927
      Location:339487
      cyclophilin_WD40; cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) having a WD40 domain. This group consists of several hypothetical and putative eukaryotic and bacterial proteins which have a cyclophilin domain and a WD40 domain. Function of the ...
      sd00039
      Location:2365
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:109236
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_001780782.3 RNA Sequence

    2. XR_003950450.2 RNA Sequence

    3. XR_873754.3 RNA Sequence

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