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    Fxr2 FMR1 autosomal homolog 2 [ Mus musculus (house mouse) ]

    Gene ID: 23879, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fxr2provided by MGI
    Official Full Name
    FMR1 autosomal homolog 2provided by MGI
    Primary source
    MGI:MGI:1346074
    See related
    Ensembl:ENSMUSG00000018765 AllianceGenome:MGI:1346074
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FXR2P; Fxr2h
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; protein dimerization activity; and translation regulator activity. Involved in dentate gyrus development and mRNA destabilization. Located in dendrite and ribosome. Is active in cytoplasm; glutamatergic synapse; and postsynapse. Is expressed in central nervous system; female reproductive system; peripheral nervous system; sensory organ; and skin. Orthologous to human FXR2 (FMR1 autosomal homolog 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 38.9), CNS E14 (RPKM 36.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Fxr2 in Genome Data Viewer
    Location:
    11 B3; 11 42.86 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69523788..69544123)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69632971..69653297)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene spermidine/spermine N1-acetyl transferase 2 Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene microRNA 467f Neighboring gene SRY (sex determining region Y)-box 15 Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene STARR-positive B cell enhancer ABC_E3965 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:69476301-69476484 Neighboring gene microRNA 1934

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in animal organ development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dentate gyrus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of long-term neuronal synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation at presynapse, modulating synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic stress granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasmic stress granule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011814.2NP_035944.2  RNA-binding protein FXR2

      See identical proteins and their annotated locations for NP_035944.2

      Status: VALIDATED

      Source sequence(s)
      BC062971
      Consensus CDS
      CCDS24901.1
      UniProtKB/Swiss-Prot
      Q9WVR4, Q9WVR5
      UniProtKB/TrEMBL
      Q6P5B5
      Related
      ENSMUSP00000018909.4, ENSMUST00000018909.4
      Conserved Domains (5) summary
      smart00322
      Location:230290
      KH; K homology RNA-binding domain
      cd00105
      Location:296362
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam05641
      Location:72129
      Agenet; Agenet domain
      pfam12235
      Location:364482
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16096
      Location:512579
      FXR_C1; Fragile X-related 1 protein C-terminal region 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69523788..69544123
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156681.1XP_036012574.1  RNA-binding protein FXR2 isoform X1

      Conserved Domains (6) summary
      pfam12235
      Location:168279
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16096
      Location:316383
      FXR_C1; Fragile X-related 1 protein C-terminal region 2
      pfam17904
      Location:121
      KH_9; FMRP KH0 domain
      NF033845
      Location:247467
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cd22508
      Location:3294
      KH_I_FXR2_rpt2; second type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins
      cd22511
      Location:95172
      KH_I_FXR2_rpt3; third type I K homology (KH) RNA-binding domain found in fragile X mental retardation syndrome-related protein 2 (FXR2) and similar proteins