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    Fxr2 fragile X mental retardation, autosomal homolog 2 [ Mus musculus (house mouse) ]

    Gene ID: 23879, updated on 9-Sep-2018

    Summary

    Official Symbol
    Fxr2provided by MGI
    Official Full Name
    fragile X mental retardation, autosomal homolog 2provided by MGI
    Primary source
    MGI:MGI:1346074
    See related
    Ensembl:ENSMUSG00000018765 Vega:OTTMUSG00000006005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fxr2h
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 38.9), CNS E14 (RPKM 36.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Fxr2 in Genome Data Viewer
    Location:
    11 B3; 11 42.86 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (69632971..69653297)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (69446473..69466799)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene spermidine/spermine N1-acetyl transferase 2 Neighboring gene 40S ribosomal protein S15a pseudogene Neighboring gene microRNA 467f Neighboring gene SRY (sex determining region Y)-box 15 Neighboring gene mannose-P-dolichol utilization defect 1 Neighboring gene microRNA 1934

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    translation regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polysome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    polysome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    fragile X mental retardation syndrome-related protein 2
    Names
    fragile X mental retardation gene 2, autosomal homolog
    fragile X mental retardation-related protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011814.2NP_035944.2  fragile X mental retardation syndrome-related protein 2

      See identical proteins and their annotated locations for NP_035944.2

      Status: VALIDATED

      Source sequence(s)
      BC062971
      Consensus CDS
      CCDS24901.1
      UniProtKB/TrEMBL
      Q6P5B5
      Related
      ENSMUSP00000018909.3, OTTMUSP00000006226, ENSMUST00000018909.3, OTTMUST00000013449
      Conserved Domains (5) summary
      smart00322
      Location:230290
      KH; K homology RNA-binding domain
      cd00105
      Location:296362
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      pfam05641
      Location:72129
      Agenet; Agenet domain
      pfam12235
      Location:364482
      FXMRP1_C_core; Fragile X-related 1 protein core C terminal
      pfam16096
      Location:512579
      FXR_C1; Fragile X-related 1 protein C-terminal region 2

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      69632971..69653297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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