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    Farsb phenylalanyl-tRNA synthetase, beta subunit [ Mus musculus (house mouse) ]

    Gene ID: 23874, updated on 23-Jun-2021

    Summary

    Official Symbol
    Farsbprovided by MGI
    Official Full Name
    phenylalanyl-tRNA synthetase, beta subunitprovided by MGI
    Primary source
    MGI:MGI:1346035
    See related
    Ensembl:ENSMUSG00000026245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F; Fa; Fr; Frsb; Farsa; Farsl; C76708; Farslb
    Expression
    Ubiquitous expression in placenta adult (RPKM 23.6), liver E14 (RPKM 19.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Farsb in Genome Data Viewer
    Location:
    1; 1 C4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (78394595..78465534, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (78417958..78488897, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (78421411..78485421, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene predicted gene, 51634 Neighboring gene proteasome (prosome, macropain) subunit, alpha type 2 pseudogene Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene predicted gene, 39665 Neighboring gene RIKEN cDNA 5730419F03 gene Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phenylalanine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in phenylalanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of phenylalanine-tRNA ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    phenylalanine--tRNA ligase beta subunit
    Names
    PheRS alpha
    phenylalanine tRNA synthetase alpha
    phenylalanine--tRNA ligase beta chain
    phenylalanine-tRNA synthetase-like, beta subunit
    phenylalanyl-tRNA synthetase beta chain
    NP_001265004.1
    NP_035941.2
    XP_036020538.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278075.1NP_001265004.1  phenylalanine--tRNA ligase beta subunit

      See identical proteins and their annotated locations for NP_001265004.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158559, AK012154, AK045432
      Consensus CDS
      CCDS15084.1
      UniProtKB/Swiss-Prot
      Q9WUA2
      UniProtKB/TrEMBL
      Q9CZU5
      Related
      ENSMUSP00000129828.2, ENSMUST00000170217.8
      Conserved Domains (4) summary
      smart00873
      Location:118279
      B3_4; B3/4 domain
      PLN02265
      Location:1589
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain
      cd00769
      Location:392588
      PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
      pfam03484
      Location:310374
      B5; tRNA synthetase B5 domain
    2. NM_011811.4NP_035941.2  phenylalanine--tRNA ligase beta subunit

      See identical proteins and their annotated locations for NP_035941.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest variant. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC158559, AK010271, BM212593
      Consensus CDS
      CCDS15084.1
      UniProtKB/Swiss-Prot
      Q9WUA2
      Related
      ENSMUSP00000069508.8, ENSMUST00000068333.14
      Conserved Domains (4) summary
      smart00873
      Location:118279
      B3_4; B3/4 domain
      PLN02265
      Location:1589
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain
      cd00769
      Location:392588
      PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
      pfam03484
      Location:310374
      B5; tRNA synthetase B5 domain

    RNA

    1. NR_102757.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC158559, AK012154, AK045432, BM212593, CN693684
      Related
      ENSMUST00000189529.7
    2. NR_102758.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC158559, AK010271, AK134799, BM212593

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      78394595..78465534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164645.1XP_036020538.1  phenylalanine--tRNA ligase beta subunit isoform X1

      Conserved Domains (1) summary
      PLN02265
      Location:27595
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain

    RNA

    1. XR_865550.2 RNA Sequence

    2. XR_004942238.1 RNA Sequence

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