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    Dmtf1 cyclin D binding myb like transcription factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 23857, updated on 27-Nov-2024

    Summary

    Official Symbol
    Dmtf1provided by MGI
    Official Full Name
    cyclin D binding myb like transcription factor 1provided by MGI
    Primary source
    MGI:MGI:1344415
    See related
    Ensembl:ENSMUSG00000042508 AllianceGenome:MGI:1344415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dimp; Dmp1
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Orthologous to human DMTF1 (cyclin D binding myb like transcription factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 13.2), CNS E18 (RPKM 12.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Dmtf1 in Genome Data Viewer
    Location:
    5 A1; 5 3.69 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (9168868..9211782, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (9118868..9161806, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12400 Neighboring gene coiled-coil domain-containing protein 72 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr5:8997064-8997365 Neighboring gene carnitine O-octanoyltransferase Neighboring gene STARR-seq mESC enhancer starr_12401 Neighboring gene STARR-seq mESC enhancer starr_12402 Neighboring gene STARR-seq mESC enhancer starr_12403 Neighboring gene predicted gene, 40264 Neighboring gene STARR-seq mESC enhancer starr_12404 Neighboring gene STARR-seq mESC enhancer starr_12405 Neighboring gene STARR-seq mESC enhancer starr_12406 Neighboring gene transmembrane protein 243, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E10301 Neighboring gene predicted gene, 46901 Neighboring gene predicted gene, 24666 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General protein information

    Preferred Names
    cyclin-D-binding Myb-like transcription factor 1
    Names
    D-interacting myb-like protein
    cyclin D binding myb-like transcription factor 1D-interacting myb-like protein
    cyclin-D-interacting Myb-like protein 1
    mDmp1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110327.2NP_001103797.1  cyclin-D-binding Myb-like transcription factor 1 isoform 2

      See identical proteins and their annotated locations for NP_001103797.1

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Consensus CDS
      CCDS51412.1
      UniProtKB/TrEMBL
      V9GXX1
      Related
      ENSMUSP00000092627.5, ENSMUST00000095017.11
      Conserved Domains (4) summary
      smart00717
      Location:274330
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:338388
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam00249
      Location:274329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    2. NM_001425525.1NP_001412454.1  cyclin-D-binding Myb-like transcription factor 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    3. NM_001425526.1NP_001412455.1  cyclin-D-binding Myb-like transcription factor 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    4. NM_001425527.1NP_001412456.1  cyclin-D-binding Myb-like transcription factor 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Related
      ENSMUSP00000139361.2, ENSMUST00000183973.8
    5. NM_001425528.1NP_001412457.1  cyclin-D-binding Myb-like transcription factor 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    6. NM_011806.4NP_035936.3  cyclin-D-binding Myb-like transcription factor 1 isoform 1

      See identical proteins and their annotated locations for NP_035936.3

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Consensus CDS
      CCDS19088.1
      UniProtKB/Swiss-Prot
      P70413, Q3TUR9, Q80VR8, Q8BQX6, Q8CA56, Q8CCZ0, Q8CE22
      UniProtKB/TrEMBL
      V9GXX1
      Related
      ENSMUSP00000071815.6, ENSMUST00000071921.13
      Conserved Domains (3) summary
      COG5147
      Location:122378
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam00249
      Location:274329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228284
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RNA

    1. NR_152858.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    2. NR_152859.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Related
      ENSMUST00000184159.8
    3. NR_152860.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    4. NR_152861.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Related
      ENSMUST00000183448.8
    5. NR_189314.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    6. NR_189315.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
      Related
      ENSMUST00000184888.8
    7. NR_189316.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    8. NR_189317.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    9. NR_189318.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121
    10. NR_189319.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC107763, AC158121

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      9168868..9211782 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165110.1XP_036021003.1  cyclin-D-binding Myb-like transcription factor 1 isoform X7

      Conserved Domains (2) summary
      smart00717
      Location:70123
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:863
      Myb_DNA-binding; Myb-like DNA-binding domain
    2. XM_036165108.1XP_036021001.1  cyclin-D-binding Myb-like transcription factor 1 isoform X6

      Conserved Domains (3) summary
      COG5147
      Location:81337
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam13921
      Location:187243
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      pfam00249
      Location:233288
      Myb_DNA-binding; Myb-like DNA-binding domain
    3. XM_036165109.1XP_036021002.1  cyclin-D-binding Myb-like transcription factor 1 isoform X7

      Conserved Domains (2) summary
      smart00717
      Location:70123
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam00249
      Location:863
      Myb_DNA-binding; Myb-like DNA-binding domain
    4. XM_011240669.2XP_011238971.1  cyclin-D-binding Myb-like transcription factor 1 isoform X3

      UniProtKB/TrEMBL
      V9GXX1
      Conserved Domains (3) summary
      COG5147
      Location:122378
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam00249
      Location:274329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228284
      Myb_DNA-bind_6; Myb-like DNA-binding domain
    5. XM_036165107.1XP_036021000.1  cyclin-D-binding Myb-like transcription factor 1 isoform X2

      UniProtKB/TrEMBL
      V9GXX1
      Conserved Domains (3) summary
      COG5147
      Location:81337
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam13921
      Location:187243
      Myb_DNA-bind_6; Myb-like DNA-binding domain
      pfam00249
      Location:233288
      Myb_DNA-binding; Myb-like DNA-binding domain
    6. XM_011240668.3XP_011238970.1  cyclin-D-binding Myb-like transcription factor 1 isoform X1

      See identical proteins and their annotated locations for XP_011238970.1

      UniProtKB/Swiss-Prot
      P70413, Q3TUR9, Q80VR8, Q8BQX6, Q8CA56, Q8CCZ0, Q8CE22
      UniProtKB/TrEMBL
      V9GXX1
      Conserved Domains (3) summary
      COG5147
      Location:122378
      REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]
      pfam00249
      Location:274329
      Myb_DNA-binding; Myb-like DNA-binding domain
      pfam13921
      Location:228284
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RNA

    1. XR_004942513.1 RNA Sequence