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    Dido1 death inducer-obliterator 1 [ Mus musculus (house mouse) ]

    Gene ID: 23856, updated on 31-Jan-2019

    Summary

    Official Symbol
    Dido1provided by MGI
    Official Full Name
    death inducer-obliterator 1provided by MGI
    Primary source
    MGI:MGI:1344352
    See related
    Ensembl:ENSMUSG00000038914
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    dido; DIO-1; Datf1; DATF-1; 6720461J16Rik; D130048F08Rik
    Summary
    This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.5), thymus adult (RPKM 4.0) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dido1 in Genome Data Viewer
    Location:
    2; 2 H4
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (180657963..180710028, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (180392669..180444704, complement)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene opioid growth factor receptor Neighboring gene collagen, type IX, alpha 3 Neighboring gene transcription factor-like 5 (basic helix-loop-helix) Neighboring gene predicted gene, 30345 Neighboring gene GID complex subunit 8 Neighboring gene predicted gene, 30455

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • mKIAA0333, C530043I07

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    death-inducer obliterator 1
    Names
    death inducer-obliterator-2
    death inducer-obliterator-3
    death-associated transcription factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291432.1NP_001278361.1  death-inducer obliterator 1 isoform Dido1

      See identical proteins and their annotated locations for NP_001278361.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks several exons and contains a 3' terminal exon that extends past a splice site used in variant 3. This results in a novel 3' coding region and 3' UTR compared to variant 3. The encoded isoform (Dido1, also known as isoform 1) is shorter and has a distinct C-terminus compared to isoform Dido3. Variants 1 and 4 encode the same isoform.
      Source sequence(s)
      AL732560, BC060249
      Consensus CDS
      CCDS17184.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000099344.1, ENSMUST00000103055.7
      Conserved Domains (3) summary
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:165241
      IBB; Importin beta binding domain
      pfam02724
      Location:122192
      CDC45; CDC45-like protein
    2. NM_001291433.1NP_001278362.1  death-inducer obliterator 1 isoform Dido2

      See identical proteins and their annotated locations for NP_001278362.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) contains a 3' terminal exon that extends past a splice site used in variant 3. This results in a novel 3' coding region and 3' UTR compared to variant 3. The encoded isoform (Dido2, also known as isoform 2) is shorter and has a distinct C-terminus compared to isoform Dido3. Variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AL732560
      Consensus CDS
      CCDS17183.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000099345.3, ENSMUST00000103056.9
      Conserved Domains (4) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:165241
      IBB; Importin beta binding domain
      pfam07744
      Location:10521158
      SPOC; SPOC domain
    3. NM_011805.3NP_035935.2  death-inducer obliterator 1 isoform Dido1

      See identical proteins and their annotated locations for NP_035935.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks several exons, and contains a 3' terminal exon that extends past a splice site used in variant 3. This results in a novel 3' coding region and 3' UTR compared to variant 3. The encoded isoform (Dido1, also known as isoform 1) is shorter and has a distinct C-terminus compared to isoform Dido3. Variants 1 and 4 encode the same isoform.
      Source sequence(s)
      AK014422, AK042474, AL732560
      Consensus CDS
      CCDS17184.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000119689.1, ENSMUST00000130986.7
      Conserved Domains (3) summary
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:165241
      IBB; Importin beta binding domain
      pfam02724
      Location:122192
      CDC45; CDC45-like protein
    4. NM_175551.4NP_780760.2  death-inducer obliterator 1 isoform Dido3

      See identical proteins and their annotated locations for NP_780760.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (Dido3, also known as isoform 3).
      Source sequence(s)
      AL732560
      Consensus CDS
      CCDS17182.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000084794.3, ENSMUST00000087517.9
      Conserved Domains (5) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:157299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10521158
      SPOC; SPOC domain
      pfam16495
      Location:14611499
      SWIRM-assoc_1; SWIRM-associated region 1
    5. NM_177852.4NP_808520.2  death-inducer obliterator 1 isoform Dido2

      See identical proteins and their annotated locations for NP_808520.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains a 3' terminal exon that extends past a splice site used in variant 3. This results in a novel 3' coding region and 3' UTR compared to variant 3. The encoded isoform (Dido2, also known as isoform 2) is shorter and has a distinct C-terminus compared to isoform Dido3. Variants 2 and 5 encode the same isoform.
      Source sequence(s)
      AK129117, AL732560
      Consensus CDS
      CCDS17183.1
      UniProtKB/Swiss-Prot
      Q8C9B9
      Related
      ENSMUSP00000099346.1, ENSMUST00000103057.7
      Conserved Domains (4) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam01749
      Location:165241
      IBB; Importin beta binding domain
      pfam07744
      Location:10521158
      SPOC; SPOC domain

    RNA

    1. NR_111965.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate internal exon and contains a 3' terminal exon that extends past a splice site used in variant 3. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 3, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL732560

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      180657963..180710028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500609.3XP_006500672.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006500672.1

      UniProtKB/Swiss-Prot
      Q8C9B9
      Conserved Domains (5) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:157299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10521158
      SPOC; SPOC domain
      pfam16495
      Location:14611499
      SWIRM-assoc_1; SWIRM-associated region 1
    2. XM_006500615.3XP_006500678.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006500678.1

      UniProtKB/Swiss-Prot
      Q8C9B9
      Conserved Domains (5) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:157299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10521158
      SPOC; SPOC domain
      pfam16495
      Location:14611499
      SWIRM-assoc_1; SWIRM-associated region 1
    3. XM_006500610.3XP_006500673.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006500673.1

      UniProtKB/Swiss-Prot
      Q8C9B9
      Conserved Domains (5) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:157299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10521158
      SPOC; SPOC domain
      pfam16495
      Location:14611499
      SWIRM-assoc_1; SWIRM-associated region 1
    4. XM_006500608.3XP_006500671.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006500671.1

      UniProtKB/Swiss-Prot
      Q8C9B9
      Conserved Domains (5) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:157299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10521158
      SPOC; SPOC domain
      pfam16495
      Location:14611499
      SWIRM-assoc_1; SWIRM-associated region 1
    5. XM_006500616.3XP_006500679.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006500679.1

      UniProtKB/Swiss-Prot
      Q8C9B9
      Conserved Domains (5) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:157299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10521158
      SPOC; SPOC domain
      pfam16495
      Location:14611499
      SWIRM-assoc_1; SWIRM-associated region 1
    6. XM_006500611.3XP_006500674.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006500674.1

      UniProtKB/Swiss-Prot
      Q8C9B9
      Conserved Domains (5) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:157299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10521158
      SPOC; SPOC domain
      pfam16495
      Location:14611499
      SWIRM-assoc_1; SWIRM-associated region 1
    7. XM_006500612.3XP_006500675.1  death-inducer obliterator 1 isoform X1

      See identical proteins and their annotated locations for XP_006500675.1

      UniProtKB/Swiss-Prot
      Q8C9B9
      Conserved Domains (5) summary
      smart00510
      Location:669770
      TFS2M; Domain in the central regions of transcription elongation factor S-II (and elsewhere)
      COG5034
      Location:157299
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd15639
      Location:263316
      PHD_DIDO1_like; PHD finger found in death-inducer obliterator variants Dido1, Dido2, and Dido3
      pfam07744
      Location:10521158
      SPOC; SPOC domain
      pfam16495
      Location:14611499
      SWIRM-assoc_1; SWIRM-associated region 1
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