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    Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 238505, updated on 31-Jan-2019

    Summary

    Official Symbol
    Mtrprovided by MGI
    Official Full Name
    5-methyltetrahydrofolate-homocysteine methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:894292
    See related
    Ensembl:ENSMUSG00000021311
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MS; AI894170; D830038K18Rik
    Expression
    Ubiquitous expression in heart adult (RPKM 14.2), limb E14.5 (RPKM 5.2) and 22 other tissues See more
    Orthologs

    Genomic context

    See Mtr in Genome Data Viewer
    Location:
    13 A1; 13 4.52 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 13 NC_000079.6 (12182720..12258193, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (12279086..12350267, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene ryanodine receptor 2, cardiac Neighboring gene ribosomal protein S7 pseudogene Neighboring gene predicted gene 10336 Neighboring gene actinin alpha 2 Neighboring gene predicted gene, 30026 Neighboring gene predicted gene, 40667

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    cobalamin binding IEA
    Inferred from Electronic Annotation
    more info
     
    folic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    methionine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    methionine synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methionine synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    axon regeneration ISO
    Inferred from Sequence Orthology
    more info
     
    cellular amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to nitric oxide ISO
    Inferred from Sequence Orthology
    more info
     
    cobalamin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    homocysteine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    methionine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    methionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    methionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    methylation IEA
    Inferred from Electronic Annotation
    more info
     
    protein methylation ISO
    Inferred from Sequence Orthology
    more info
     
    pteridine-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    response to axon injury ISO
    Inferred from Sequence Orthology
    more info
     
    tetrahydrofolate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    methionine synthase
    Names
    vitamin-B12 dependent methionine synthase
    NP_001074597.1
    XP_006516724.1
    XP_006516725.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081128.3NP_001074597.1  methionine synthase

      See identical proteins and their annotated locations for NP_001074597.1

      Status: VALIDATED

      Source sequence(s)
      AI894170, BB630813, BC145683
      Consensus CDS
      CCDS36591.1
      UniProtKB/Swiss-Prot
      A6H5Y3
      Related
      ENSMUSP00000097442.4, ENSMUST00000099856.5
      Conserved Domains (5) summary
      COG0646
      Location:8328
      MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
      PRK09490
      Location:11249
      metH; B12-dependent methionine synthase; Provisional
      cd00740
      Location:359615
      MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
      cd02069
      Location:659885
      methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
      pfam02965
      Location:9541234
      Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p4 C57BL/6J

      Range
      12182720..12258193 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516661.3XP_006516724.1  methionine synthase isoform X1

      Conserved Domains (5) summary
      COG1410
      Location:76964
      MetH2; Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]
      cd00740
      Location:105361
      MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
      cd02069
      Location:405631
      methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
      pfam02965
      Location:700980
      Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
      cl22882
      Location:174
      S-methyl_trans; Homocysteine S-methyltransferase
    2. XM_006516662.3XP_006516725.1  methionine synthase isoform X2

      Conserved Domains (4) summary
      COG0646
      Location:8328
      MetH1; Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]
      cd00740
      Location:359615
      MeTr; MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent ...
      cd02069
      Location:659885
      methionine_synthase_B12_BD; B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy).
      pfam02965
      Location:954991
      Met_synt_B12; Vitamin B12 dependent methionine synthase, activation domain
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