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    Capn10 calpain 10 [ Mus musculus (house mouse) ]

    Gene ID: 23830, updated on 23-Jun-2021

    Summary

    Official Symbol
    Capn10provided by MGI
    Official Full Name
    calpain 10provided by MGI
    Primary source
    MGI:MGI:1344392
    See related
    Ensembl:ENSMUSG00000026270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ca; Capn8; AW049679; mKIAA1845
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 19.1), ovary adult (RPKM 16.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Capn10 in Genome Data Viewer
    Location:
    1; 1 D
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92862130..92875670)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (92934408..92947948)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (94830985..94844525)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5033417F24 gene Neighboring gene dual specificity phosphatase 28 Neighboring gene arginyl aminopeptidase (aminopeptidase B)-like 1 Neighboring gene RIKEN cDNA 9430060I03 gene Neighboring gene G protein-coupled receptor 35 Neighboring gene predicted gene, 36424

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SNARE binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium-dependent cysteine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton reorganization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in aging ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in autophagy of mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to insulin stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of type B pancreatic cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to nutrient levels ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type B pancreatic cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in type B pancreatic cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calpain-10
    Names
    CANP 10
    calcium-activated neutral proteinase 10
    calpain 8
    NP_035926.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011796.2NP_035926.2  calpain-10

      See identical proteins and their annotated locations for NP_035926.2

      Status: VALIDATED

      Source sequence(s)
      BB747799, BC010969, BI986964
      Consensus CDS
      CCDS15181.1
      UniProtKB/Swiss-Prot
      Q9ESK3
      Related
      ENSMUSP00000027488.5, ENSMUST00000027488.11
      Conserved Domains (3) summary
      smart00720
      Location:338488
      calpain_III; calpain_III domain
      cd00044
      Location:8319
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:506647
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      92862130..92875670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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