Format

Send to:

Choose Destination
    • Showing Current items.

    Arih1 ariadne RBR E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

    Gene ID: 23806, updated on 16-Oct-2021

    Summary

    Official Symbol
    Arih1provided by MGI
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 1provided by MGI
    Primary source
    MGI:MGI:1344363
    See related
    Ensembl:ENSMUSG00000025234
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ari; Ari1; Hari; Hhari; Uip77; Ubch7bp; AU021774
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 9.4), testis adult (RPKM 8.9) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arih1 in Genome Data Viewer
    Location:
    9; 9 B
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59295837..59395469, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59388554..59488186, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (59236361..59334181, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ADP-dependent glucokinase Neighboring gene Bardet-Biedl syndrome 4 (human) Neighboring gene ribosomal protein S11, pseudogene 1 Neighboring gene predicted gene, 20199 Neighboring gene predicted gene, 33180 Neighboring gene transmembrane protein 202 Neighboring gene hexosaminidase A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin conjugating enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4A-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Lewy body ISO
    Inferred from Sequence Orthology
    more info
     
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase ARIH1
    Names
    ARI-1
    RING-type E3 ubiquitin transferase ARIH1
    UbcH7-binding protein
    UbcM4-interacting protein 77
    ariadne 1
    ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1
    protein ariadne-1 homolog
    ubiquitin-conjugating enzyme E2-binding protein 1
    NP_064311.2
    XP_006511203.1
    XP_006511204.1
    XP_011241041.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019927.2NP_064311.2  E3 ubiquitin-protein ligase ARIH1

      See identical proteins and their annotated locations for NP_064311.2

      Status: VALIDATED

      Source sequence(s)
      AJ130977, AK032640, AK047617, AW125831, CA328699, CJ176800, CK633971, CV555932
      Consensus CDS
      CCDS52817.1
      UniProtKB/Swiss-Prot
      Q9Z1K5
      Related
      ENSMUSP00000126531.2, ENSMUST00000171975.8
      Conserved Domains (3) summary
      smart00647
      Location:255315
      IBR; In Between Ring fingers
      cd16626
      Location:183240
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:337377
      IBR; IBR domain, a half RING-finger domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      59295837..59395469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511140.4XP_006511203.1  E3 ubiquitin-protein ligase ARIH1 isoform X1

      Conserved Domains (3) summary
      smart00647
      Location:196256
      IBR; In Between Ring fingers
      cd16626
      Location:124181
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:278318
      IBR; IBR domain, a half RING-finger domain
    2. XM_006511141.3XP_006511204.1  E3 ubiquitin-protein ligase ARIH1 isoform X3

      Conserved Domains (3) summary
      smart00647
      Location:165225
      IBR; In Between Ring fingers
      cd16626
      Location:93150
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:247287
      IBR; IBR domain, a half RING-finger domain
    3. XM_011242739.3XP_011241041.1  E3 ubiquitin-protein ligase ARIH1 isoform X2

      Conserved Domains (3) summary
      smart00647
      Location:173233
      IBR; In Between Ring fingers
      cd16626
      Location:101158
      RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
      pfam01485
      Location:255295
      IBR; IBR domain, a half RING-finger domain

    RNA

    1. XR_004935434.1 RNA Sequence

    Support Center