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    Akt3 thymoma viral proto-oncogene 3 [ Mus musculus (house mouse) ]

    Gene ID: 23797, updated on 27-Nov-2024

    Summary

    Official Symbol
    Akt3provided by MGI
    Official Full Name
    thymoma viral proto-oncogene 3provided by MGI
    Primary source
    MGI:MGI:1345147
    See related
    Ensembl:ENSMUSG00000019699 AllianceGenome:MGI:1345147
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nmf350; D930002M15Rik
    Summary
    Predicted to enable ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of angiogenesis and positive regulation of artery morphogenesis. Acts upstream of or within several processes, including brain morphogenesis; positive regulation of TOR signaling; and positive regulation of cell size. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; nervous system; and retina. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 12.2), CNS E14 (RPKM 10.5) and 22 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Akt3 in Genome Data Viewer
    Location:
    1 H4; 1 82.66 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (176847642..177091688, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (177020076..177261781, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5862 Neighboring gene serologically defined colon cancer antigen 8 Neighboring gene high mobility group AT-hook 2, pseudogene 1 Neighboring gene predicted gene, 38158 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:178876211-178876412 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:178880303-178880504 Neighboring gene predicted gene 15423 Neighboring gene STARR-positive B cell enhancer ABC_E7781 Neighboring gene STARR-seq mESC enhancer starr_03123 Neighboring gene predicted gene, 36904 Neighboring gene STARR-positive B cell enhancer ABC_E11110 Neighboring gene STARR-positive B cell enhancer mm9_chr1:179371945-179372246 Neighboring gene STARR-positive B cell enhancer ABC_E3338 Neighboring gene zinc finger and BTB domain containing 18 Neighboring gene keratin 8 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within brain morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitochondrial genome maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of PERK-mediated unfolded protein response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of cellular senescence IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cellular senescence ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of TOR signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of artery morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of sodium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of vascular endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    RAC-gamma serine/threonine-protein kinase
    Names
    PKB gamma
    RAC-PK-gamma
    protein kinase Akt-3
    protein kinase B gamma
    NP_035915.3
    XP_006496881.1
    XP_006496882.1
    XP_011237107.1
    XP_030109770.1
    XP_030109777.1
    XP_036020522.1
    XP_036020523.1
    XP_036020524.1
    XP_036020525.1
    XP_036020526.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011785.4NP_035915.3  RAC-gamma serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_035915.3

      Status: VALIDATED

      Source sequence(s)
      AC130843, AC163009, AK052953, BF455585, CD578931
      Consensus CDS
      CCDS35799.1
      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q6NXW0
      Related
      ENSMUSP00000106790.3, ENSMUST00000111160.9
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      176847642..177091688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164629.1XP_036020522.1  RAC-gamma serine/threonine-protein kinase isoform X3

      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cl21453
      Location:132438
      PKc_like; Protein Kinases, catalytic domain
    2. XM_006496818.5XP_006496881.1  RAC-gamma serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006496881.1

      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q6NXW0
      Related
      ENSMUSP00000106789.2, ENSMUST00000111159.2
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    3. XM_036164632.1XP_036020525.1  RAC-gamma serine/threonine-protein kinase isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:46292
      PKc_like; Protein Kinases, catalytic domain
    4. XM_036164631.1XP_036020524.1  RAC-gamma serine/threonine-protein kinase isoform X6

      Conserved Domains (1) summary
      cd05593
      Location:16363
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    5. XM_036164630.1XP_036020523.1  RAC-gamma serine/threonine-protein kinase isoform X5

      Conserved Domains (2) summary
      cl17171
      Location:149
      PH-like; Pleckstrin homology-like domain
      cl21453
      Location:71377
      PKc_like; Protein Kinases, catalytic domain
    6. XM_030253917.2XP_030109777.1  RAC-gamma serine/threonine-protein kinase isoform X4

      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd05593
      Location:71418
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
      cl17171
      Location:149
      PH-like; Pleckstrin homology-like domain
    7. XM_030253910.1XP_030109770.1  RAC-gamma serine/threonine-protein kinase isoform X1

      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    8. XM_036164633.1XP_036020526.1  RAC-gamma serine/threonine-protein kinase isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:46292
      PKc_like; Protein Kinases, catalytic domain
    9. XM_006496819.5XP_006496882.1  RAC-gamma serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006496882.1

      UniProtKB/Swiss-Prot
      Q9WUA6
      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cd05593
      Location:132479
      STKc_PKB_gamma; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3)
    10. XM_011238805.4XP_011237107.1  RAC-gamma serine/threonine-protein kinase isoform X2

      UniProtKB/TrEMBL
      Q6NXW0
      Conserved Domains (2) summary
      cd01241
      Location:4110
      PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain
      cl21453
      Location:152417
      PKc_like; Protein Kinases, catalytic domain