Format

Send to:

Choose Destination
    • Showing Current items.

    Brip1 BRCA1 interacting protein C-terminal helicase 1 [ Mus musculus (house mouse) ]

    Gene ID: 237911, updated on 31-Jan-2019

    Summary

    Official Symbol
    Brip1provided by MGI
    Official Full Name
    BRCA1 interacting protein C-terminal helicase 1provided by MGI
    Primary source
    MGI:MGI:2442836
    See related
    Ensembl:ENSMUSG00000034329
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OF; FACJ; Bach1; Fancj; 3110009N10Rik; 8030460J03Rik
    Summary
    This gene encodes a member of the DEAH subfamily of DEAD box helicases. A similar protein in humans is both a DNA-dependent ATPase and a 5-prime-to-3-prime DNA helicase, and plays a role in the repair of DNA double stranded breaks through interaction with the breast cancer-associated tumor suppressor BRCA1. [provided by RefSeq, Feb 2011]
    Expression
    Biased expression in CNS E11.5 (RPKM 1.7), liver E14 (RPKM 1.5) and 13 other tissues See more
    Orthologs

    Genomic context

    See Brip1 in Genome Data Viewer
    Location:
    11; 11 C
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (86058131..86201267, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (85871640..86014695, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene predicted gene, 20759 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, pseudogene 2 Neighboring gene BRCA1 interacting protein C-terminal helicase 1, opposite strand Neighboring gene integrator complex subunit 2 Neighboring gene nuclear encoded tRNA glutamine 2 (anticodon TTG)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATP-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides IEA
    Inferred from Electronic Annotation
    more info
     
    iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    chiasma assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair involved in meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    double-strand break repair involved in meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male gonad development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    meiotic DNA double-strand break processing involved in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide-excision repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    seminiferous tubule development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogonial cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synapsis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    Fanconi anemia group J protein homolog
    Names
    ATP-dependent RNA helicase BRIP1
    BRCA1-associated C-terminal helicase 1
    NP_840094.1
    XP_006533302.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178309.2NP_840094.1  Fanconi anemia group J protein homolog

      See identical proteins and their annotated locations for NP_840094.1

      Status: REVIEWED

      Source sequence(s)
      AK051878, AK080771, BC094252, CJ240209
      Consensus CDS
      CCDS25197.1
      UniProtKB/Swiss-Prot
      Q5SXJ3
      Related
      ENSMUSP00000043108.3, ENSMUST00000044423.3
      Conserved Domains (3) summary
      TIGR00604
      Location:248884
      rad3; DNA repair helicase (rad3)
      pfam06733
      Location:251418
      DEAD_2; DEAD_2
      pfam13307
      Location:683869
      Helicase_C_2; Helicase C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      86058131..86201267 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533239.2XP_006533302.1  Fanconi anemia group J protein homolog isoform X1

      See identical proteins and their annotated locations for XP_006533302.1

      UniProtKB/Swiss-Prot
      Q5SXJ3
      Conserved Domains (3) summary
      TIGR00604
      Location:248884
      rad3; DNA repair helicase (rad3)
      pfam06733
      Location:251418
      DEAD_2; DEAD_2
      pfam13307
      Location:683869
      Helicase_C_2; Helicase C-terminal domain

    RNA

    1. XR_879647.1 RNA Sequence

    Support Center