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    Coro1b coronin, actin binding protein 1B [ Mus musculus (house mouse) ]

    Gene ID: 23789, updated on 24-Apr-2022

    Summary

    Official Symbol
    Coro1bprovided by MGI
    Official Full Name
    coronin, actin binding protein 1Bprovided by MGI
    Primary source
    MGI:MGI:1345963
    See related
    Ensembl:ENSMUSG00000024835 AllianceGenome:MGI:1345963
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable Arp2/3 complex binding activity; actin filament binding activity; and identical protein binding activity. Predicted to be involved in several processes, including actin filament organization; cellular response to platelet-derived growth factor stimulus; and regulation of lamellipodium morphogenesis. Predicted to be located in several cellular components, including actin cytoskeleton; lamellipodium; and perinuclear region of cytoplasm. Is expressed in several structures, including brain; dorsal root ganglion; genitourinary system; liver; and spleen. Orthologous to human CORO1B (coronin 1B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 222.9), large intestine adult (RPKM 168.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Coro1b in Genome Data Viewer
    Location:
    19 A; 19 3.85 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4198603..4204034)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4148611..4154035)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (4148663..4154035)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene calcium binding protein 4 Neighboring gene G protein-coupled receptor 152 Neighboring gene protein tyrosine phosphatase, receptor type, C polypeptide-associated protein Neighboring gene ribosomal protein S6 kinase, polypeptide 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Arp2/3 complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament branching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to platelet-derived growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in endothelial cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of Arp2/3 complex-mediated actin nucleation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of smooth muscle cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of lamellipodium morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein kinase C signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein localization to cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell leading edge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell periphery ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    coronin-1B
    Names
    coronin 1b
    coronin-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011778.3NP_035908.1  coronin-1B

      See identical proteins and their annotated locations for NP_035908.1

      Status: VALIDATED

      Source sequence(s)
      AC109138
      Consensus CDS
      CCDS29418.1
      UniProtKB/Swiss-Prot
      Q9WUM3
      UniProtKB/TrEMBL
      A2RS22
      Related
      ENSMUSP00000008893.9, ENSMUST00000008893.9
      Conserved Domains (2) summary
      sd00039
      Location:3880
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      4198603..4204034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531742.2XP_006531805.1  coronin-1B isoform X1

      See identical proteins and their annotated locations for XP_006531805.1

      UniProtKB/Swiss-Prot
      Q9WUM3
      UniProtKB/TrEMBL
      A2RS22
      Conserved Domains (2) summary
      sd00039
      Location:3880
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_036161585.1XP_036017478.1  coronin-1B isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:4782
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:18347
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_036161586.1XP_036017479.1  coronin-1B isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:4782
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:18347
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. XM_036161587.1XP_036017480.1  coronin-1B isoform X2

      Conserved Domains (2) summary
      sd00039
      Location:4782
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:18347
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. XM_006531741.4XP_006531804.1  coronin-1B isoform X1

      See identical proteins and their annotated locations for XP_006531804.1

      UniProtKB/Swiss-Prot
      Q9WUM3
      UniProtKB/TrEMBL
      A2RS22
      Conserved Domains (2) summary
      sd00039
      Location:3880
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10480
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...