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    Atad5 ATPase family, AAA domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 237877, updated on 31-Jan-2019

    Summary

    Official Symbol
    Atad5provided by MGI
    Official Full Name
    ATPase family, AAA domain containing 5provided by MGI
    Primary source
    MGI:MGI:2442925
    See related
    Ensembl:ENSMUSG00000017550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm17; FRAG1; C130052G03Rik
    Expression
    Biased expression in liver E14 (RPKM 5.8), CNS E11.5 (RPKM 5.5) and 14 other tissues See more
    Orthologs

    Genomic context

    See Atad5 in Genome Data Viewer
    Location:
    11; 11 B5
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (80089379..80135797)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (79902902..79949293)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene SUZ12 polycomb repressive complex 2 subunit Neighboring gene cytokine receptor-like factor 3 Neighboring gene transcription elongation factor, mitochondrial Neighboring gene ArfGAP with dual PH domains 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • FLJ12735

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA clamp unloader activity ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA clamp unloading ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    isotype switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nuclear DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    nucleic acid phosphodiester bond hydrolysis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell cycle G2/M phase transition ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of isotype switching to IgG isotypes IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of mitotic cell cycle phase transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction in response to DNA damage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Elg1 RFC-like complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ATPase family AAA domain-containing protein 5
    Names
    chromosome fragility associated gene 1
    chromosome fragility-associated gene 1 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029856.2NP_001025027.1  ATPase family AAA domain-containing protein 5

      See identical proteins and their annotated locations for NP_001025027.1

      Status: VALIDATED

      Source sequence(s)
      AL591113, AL663057, AL672178
      Consensus CDS
      CCDS25127.1
      UniProtKB/Swiss-Prot
      Q4QY64
      Related
      ENSMUSP00000017694.5, ENSMUST00000017694.6
      Conserved Domains (1) summary
      cl21455
      Location:11151160
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      80089379..80135797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533233.2XP_006533296.1  ATPase family AAA domain-containing protein 5 isoform X2

      Conserved Domains (1) summary
      cl21455
      Location:11151160
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. XM_006533234.3XP_006533297.1  ATPase family AAA domain-containing protein 5 isoform X3

      Conserved Domains (1) summary
      cl21455
      Location:11151160
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    3. XM_006533232.3XP_006533295.1  ATPase family AAA domain-containing protein 5 isoform X1

      UniProtKB/TrEMBL
      Z4YKQ9
      Related
      ENSMUSP00000103874.1, ENSMUST00000108239.6
      Conserved Domains (1) summary
      cl21455
      Location:11121157
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    4. XM_011248989.2XP_011247291.1  ATPase family AAA domain-containing protein 5 isoform X4

      Conserved Domains (1) summary
      cl21455
      Location:477522
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    5. XM_017314529.1XP_017170018.1  ATPase family AAA domain-containing protein 5 isoform X5

    RNA

    1. XR_001780002.1 RNA Sequence

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