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    Osbpl8 oxysterol binding protein-like 8 [ Mus musculus (house mouse) ]

    Gene ID: 237542, updated on 23-Jun-2021

    Summary

    Official Symbol
    Osbpl8provided by MGI
    Official Full Name
    oxysterol binding protein-like 8provided by MGI
    Primary source
    MGI:MGI:2443807
    See related
    Ensembl:ENSMUSG00000020189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OR; ORP-8; AA536976; AA536995; C730029P18Rik; D330025H14Rik
    Summary
    This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 7.5), frontal lobe adult (RPKM 6.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Osbpl8 in Genome Data Viewer
    Location:
    10; 10 D1
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111000663..111133110)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111164742..111297249)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (110601858..110734303)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L6-like Neighboring gene coiled-coil domain containing 99 pseudogene Neighboring gene predicted gene, 17849 Neighboring gene microRNA 12180 Neighboring gene predicted gene, 40760 Neighboring gene Bardet-Biedl syndrome 10 (human) Neighboring gene predicted gene, 30095

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cholesterol binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylserine transfer activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables sterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables sterol transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cortical endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    oxysterol-binding protein-related protein 8
    Names
    OSBP-related protein 8

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003717.1NP_001003717.1  oxysterol-binding protein-related protein 8 isoform b

      See identical proteins and their annotated locations for NP_001003717.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, resulting in the use of a downstream in-frame start codon compared to variant 1. Variant 2 encodes isoform b, which has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AA536976, AK037869, AK050244, AK052311, BU152326, CF745582
      Consensus CDS
      CCDS24166.1
      UniProtKB/Swiss-Prot
      B9EJ86
      UniProtKB/TrEMBL
      A0A0R4J150
      Related
      ENSMUSP00000092948.2, ENSMUST00000095310.3
      Conserved Domains (2) summary
      cd13286
      Location:100229
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:365702
      Oxysterol_BP; Oxysterol-binding protein
    2. NM_175489.3NP_780698.2  oxysterol-binding protein-related protein 8 isoform a

      See identical proteins and their annotated locations for NP_780698.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AA536976, AK037158, AK037869, AK050244, AK052311, BU152326, CF745582
      Consensus CDS
      CCDS36056.1
      UniProtKB/Swiss-Prot
      B9EJ86
      Related
      ENSMUSP00000100911.2, ENSMUST00000105275.9
      Conserved Domains (3) summary
      cd13286
      Location:142271
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam00169
      Location:149265
      PH; PH domain
      pfam01237
      Location:407745
      Oxysterol_BP; Oxysterol-binding protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      111000663..111133110
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155782.1XP_036011675.1  oxysterol-binding protein-related protein 8 isoform X3

      Conserved Domains (2) summary
      cd13286
      Location:100229
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:365702
      Oxysterol_BP; Oxysterol-binding protein
    2. XM_006513637.4XP_006513700.1  oxysterol-binding protein-related protein 8 isoform X1

      Conserved Domains (2) summary
      cd13286
      Location:139268
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:404741
      Oxysterol_BP; Oxysterol-binding protein
    3. XM_006513638.2XP_006513701.1  oxysterol-binding protein-related protein 8 isoform X2

      See identical proteins and their annotated locations for XP_006513701.1

      Related
      ENSMUSP00000158904.2, ENSMUST00000238838.2
      Conserved Domains (2) summary
      cd13286
      Location:118247
      PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
      pfam01237
      Location:383720
      Oxysterol_BP; Oxysterol-binding protein
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