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    Tmtc3 transmembrane and tetratricopeptide repeat containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 237500, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tmtc3provided by MGI
    Official Full Name
    transmembrane and tetratricopeptide repeat containing 3provided by MGI
    Primary source
    MGI:MGI:3036255
    See related
    Ensembl:ENSMUSG00000036676
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mSm; mSmile; 9130014E20Rik; B130008E12Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 3.8), bladder adult (RPKM 3.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tmtc3 in Genome Data Viewer
    Location:
    10; 10 D1
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (100279764..100323230, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (100443902..100487365, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (99906536..99949981, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene 4312 Neighboring gene THO complex 4 pseudogene Neighboring gene centrosomal protein 290 Neighboring gene RIKEN cDNA 4930430F08 gene Neighboring gene RIKEN cDNA 1700017N19 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables mannosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein O-mannosyl-transferase TMTC3
    Names
    transmembrane and TPR repeat-containing protein 3
    NP_001028504.1
    NP_001103483.1
    XP_006513693.1
    XP_011241751.1
    XP_011241752.1
    XP_017169426.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033332.2NP_001028504.1  protein O-mannosyl-transferase TMTC3 isoform 2

      See identical proteins and their annotated locations for NP_001028504.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, creating a novel segment containing a premature stop codon when compared to variant 1. This results in a shorter protein (isoform 2) with a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK165838
      Consensus CDS
      CCDS24150.1
      UniProtKB/Swiss-Prot
      Q8BRH0
      UniProtKB/TrEMBL
      A0A0R4J173
      Related
      ENSMUSP00000096921.4, ENSMUST00000099318.10
      Conserved Domains (4) summary
      sd00006
      Location:535562
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:602635
      TPR_1; Tetratricopeptide repeat
      pfam08409
      Location:263336
      DUF1736; Domain of unknown function (DUF1736)
      pfam13414
      Location:569633
      TPR_11; TPR repeat
    2. NM_001110013.1NP_001103483.1  protein O-mannosyl-transferase TMTC3 isoform 1

      See identical proteins and their annotated locations for NP_001103483.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153501, AK149759, AK165838
      Consensus CDS
      CCDS48684.1
      UniProtKB/Swiss-Prot
      Q8BRH0
      UniProtKB/TrEMBL
      G5E8C4
      Related
      ENSMUSP00000061470.9, ENSMUST00000058154.15
      Conserved Domains (3) summary
      TIGR02917
      Location:448807
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:535562
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:263336
      DUF1736; Domain of unknown function (DUF1736)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      100279764..100323230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011243450.4XP_011241752.1  protein O-mannosyl-transferase TMTC3 isoform X1

      See identical proteins and their annotated locations for XP_011241752.1

      UniProtKB/TrEMBL
      G5E8C4
      Conserved Domains (3) summary
      TIGR02917
      Location:448807
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:535562
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:263336
      DUF1736; Domain of unknown function (DUF1736)
    2. XM_006513630.5XP_006513693.1  protein O-mannosyl-transferase TMTC3 isoform X1

      See identical proteins and their annotated locations for XP_006513693.1

      UniProtKB/TrEMBL
      G5E8C4
      Conserved Domains (3) summary
      TIGR02917
      Location:448807
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:535562
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:263336
      DUF1736; Domain of unknown function (DUF1736)
    3. XM_011243449.4XP_011241751.1  protein O-mannosyl-transferase TMTC3 isoform X1

      See identical proteins and their annotated locations for XP_011241751.1

      UniProtKB/TrEMBL
      G5E8C4
      Conserved Domains (3) summary
      TIGR02917
      Location:448807
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:535562
      TPR; TPR repeat [structural motif]
      pfam08409
      Location:263336
      DUF1736; Domain of unknown function (DUF1736)
    4. XM_017313937.3XP_017169426.1  protein O-mannosyl-transferase TMTC3 isoform X2

      Conserved Domains (2) summary
      TIGR02917
      Location:68353
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:75102
      TPR; TPR repeat [structural motif]

    RNA

    1. XR_004936178.1 RNA Sequence

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