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    GABARAPL1 GABA type A receptor associated protein like 1 [ Homo sapiens (human) ]

    Gene ID: 23710, updated on 7-Apr-2024

    Summary

    Official Symbol
    GABARAPL1provided by HGNC
    Official Full Name
    GABA type A receptor associated protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:4068
    See related
    Ensembl:ENSG00000139112 MIM:607420; AllianceGenome:HGNC:4068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE
    Summary
    Enables Tat protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in autophagosome assembly; autophagy of mitochondrion; and cellular response to nitrogen starvation. Located in autophagosome. Colocalizes with mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 136.2), kidney (RPKM 101.2) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See GABARAPL1 in Genome Data Viewer
    Location:
    12p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (10212877..10223128)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (10099612..10109862)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10365476..10375727)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369655 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:10286337-10287157 Neighboring gene C-type lectin domain containing 7A Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:10305885-10306388 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5959 Neighboring gene MPRA-validated peak1568 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:10331989-10333188 Neighboring gene oxidized low density lipoprotein receptor 1 Neighboring gene transmembrane protein 52B Neighboring gene MPRA-validated peak1569 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4236 Neighboring gene GABARAPL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:10364713-10365255 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4237 Neighboring gene killer cell lectin like receptor D1 Neighboring gene uncharacterized LOC124902875 Neighboring gene uncharacterized LOC105369656

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GABA receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GABA receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Tat protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-tubulin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in glycophagy IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in autophagosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with mitochondrion IGI
    Inferred from Genetic Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    gamma-aminobutyric acid receptor-associated protein-like 1
    Names
    GABA(A) receptor-associated protein-like 1
    early estrogen-regulated protein
    glandular epithelial cell protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363598.2NP_001350527.1  gamma-aminobutyric acid receptor-associated protein-like 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115676, DC365706
      Consensus CDS
      CCDS86280.1
      Related
      ENSP00000411256.2, ENST00000421801.6
      Conserved Domains (1) summary
      cl28922
      Location:596
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    2. NM_031412.4NP_113600.1  gamma-aminobutyric acid receptor-associated protein-like 1 isoform 2

      See identical proteins and their annotated locations for NP_113600.1

      Status: VALIDATED

      Source sequence(s)
      AC115676, BC028315
      Consensus CDS
      CCDS8620.1
      UniProtKB/Swiss-Prot
      B4E0Y7, Q6FIE6, Q9H0R8
      UniProtKB/TrEMBL
      B2RD60
      Related
      ENSP00000266458.5, ENST00000266458.10
      Conserved Domains (1) summary
      cd16127
      Location:5111
      Ubl_ATG8_GABARAP_like; ubiquitin-like (Ubl) domain found in gamma-aminobutyric acid receptor-associated protein (GABARAP) and similar proteins; sub-family of the autophagy-related 8 (ATG8) protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      10212877..10223128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      10099612..10109862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)