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    Klhl15 kelch-like 15 [ Mus musculus (house mouse) ]

    Gene ID: 236904, updated on 22-May-2018

    Summary

    Official Symbol
    Klhl15provided by MGI
    Official Full Name
    kelch-like 15provided by MGI
    Primary source
    MGI:MGI:1923400
    See related
    Ensembl:ENSMUSG00000043929 Vega:OTTMUSG00000018085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330500C13Rik
    Expression
    Low expression observed in reference dataset See more
    Orthologs

    Genomic context

    See Klhl15 in Genome Data Viewer
    Location:
    X; X C3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (94234512..94277724)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (91480269..91518854)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein X-linked Neighboring gene predicted gene, 46691 Neighboring gene eukaryotic translation initiation factor 2, subunit 3, structural gene X-linked Neighboring gene microRNA 7673 Neighboring gene predicted gene 5400 Neighboring gene predicted gene 14826

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Clone Names

    • MGC47138

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear protein quality control by the ubiquitin-proteasome system ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    colocalizes_with Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039059.1NP_001034148.1  kelch-like protein 15 isoform c

      See identical proteins and their annotated locations for NP_001034148.1

      Status: VALIDATED

      Source sequence(s)
      AK081546, AK165342, AK169500
      Consensus CDS
      CCDS41062.1
      UniProtKB/Swiss-Prot
      A2AAX3
      Related
      ENSMUSP00000109541.1, OTTMUSP00000019616, ENSMUST00000113908.7, OTTMUST00000043657
      Conserved Domains (3) summary
      smart00225
      Location:32128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:133235
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:21125
      BTB; BTB/POZ domain
    2. NM_001039060.1NP_001034149.1  kelch-like protein 15 isoform b

      See identical proteins and their annotated locations for NP_001034149.1

      Status: VALIDATED

      Source sequence(s)
      AK081546, AK165342, AK169500
      Consensus CDS
      CCDS30279.1
      UniProtKB/Swiss-Prot
      A2AAX3
      Related
      ENSMUSP00000094097.3, OTTMUSP00000019617, ENSMUST00000096369.9, OTTMUST00000043658
      Conserved Domains (3) summary
      smart00225
      Location:32128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:133235
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:21125
      BTB; BTB/POZ domain
    3. NM_001039061.1NP_001034150.1  kelch-like protein 15 isoform a

      See identical proteins and their annotated locations for NP_001034150.1

      Status: VALIDATED

      Source sequence(s)
      AK078112, AK081546, AK133055, AL646049
      Consensus CDS
      CCDS30278.1
      UniProtKB/Swiss-Prot
      A2AAX3
      Related
      ENSMUSP00000109549.3, ENSMUST00000113916.9
      Conserved Domains (2) summary
      sd00038
      Location:417474
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:33576
      BTB; Broad-Complex, Tramtrack and Bric a brac
    4. NM_153165.2NP_694805.1  kelch-like protein 15 isoform c

      See identical proteins and their annotated locations for NP_694805.1

      Status: VALIDATED

      Source sequence(s)
      AK081546, AK165342, AK169500
      Consensus CDS
      CCDS41062.1
      UniProtKB/Swiss-Prot
      A2AAX3
      Related
      ENSMUSP00000109544.2, OTTMUSP00000019615, ENSMUST00000113911.8, OTTMUST00000043656
      Conserved Domains (3) summary
      smart00225
      Location:32128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:133235
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:21125
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      94234512..94277724
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527988.3XP_006528051.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528051.1

      UniProtKB/Swiss-Prot
      A2AAX3
      Conserved Domains (2) summary
      sd00038
      Location:417474
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:33576
      BTB; Broad-Complex, Tramtrack and Bric a brac
    2. XM_006527989.3XP_006528052.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528052.1

      UniProtKB/Swiss-Prot
      A2AAX3
      Conserved Domains (2) summary
      sd00038
      Location:417474
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:33576
      BTB; Broad-Complex, Tramtrack and Bric a brac
    3. XM_006527986.3XP_006528049.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528049.1

      UniProtKB/Swiss-Prot
      A2AAX3
      Conserved Domains (2) summary
      sd00038
      Location:417474
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:33576
      BTB; Broad-Complex, Tramtrack and Bric a brac
    4. XM_006527991.3XP_006528054.1  kelch-like protein 15 isoform X2

      See identical proteins and their annotated locations for XP_006528054.1

      UniProtKB/Swiss-Prot
      A2AAX3
      Conserved Domains (3) summary
      smart00225
      Location:32128
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00875
      Location:133235
      BACK; BTB And C-terminal Kelch
      pfam00651
      Location:21125
      BTB; BTB/POZ domain
    5. XM_006527987.2XP_006528050.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528050.1

      UniProtKB/Swiss-Prot
      A2AAX3
      Conserved Domains (2) summary
      sd00038
      Location:417474
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:33576
      BTB; Broad-Complex, Tramtrack and Bric a brac
    6. XM_006527990.3XP_006528053.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_006528053.1

      UniProtKB/Swiss-Prot
      A2AAX3
      Conserved Domains (2) summary
      sd00038
      Location:417474
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:33576
      BTB; Broad-Complex, Tramtrack and Bric a brac
    7. XM_011247581.1XP_011245883.1  kelch-like protein 15 isoform X1

      See identical proteins and their annotated locations for XP_011245883.1

      UniProtKB/Swiss-Prot
      A2AAX3
      Related
      ENSMUSP00000109548.1, OTTMUSP00000019614, ENSMUST00000113915.1, OTTMUST00000043655
      Conserved Domains (2) summary
      sd00038
      Location:417474
      Kelch; KELCH repeat [structural motif]
      cl28614
      Location:33576
      BTB; Broad-Complex, Tramtrack and Bric a brac
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