Format

Send to:

Choose Destination
    • Showing Current items.

    Phgdh 3-phosphoglycerate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 236539, updated on 23-Jun-2021

    Summary

    Official Symbol
    Phgdhprovided by MGI
    Official Full Name
    3-phosphoglycerate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:1355330
    See related
    Ensembl:ENSMUSG00000053398
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S; A1; PG; A10; PGD; 3PGD; PGAD; PGDH; SERA; 3-PGD; 3PGDH; 3-PGDH; 4930479N23
    Expression
    Broad expression in placenta adult (RPKM 138.0), genital fat pad adult (RPKM 127.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Phgdh in Genome Data Viewer
    Location:
    3; 3 F2.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (98220487..98247285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (98313171..98339969, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (98117094..98143892, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene regenerating islet-derived family, member 4 Neighboring gene 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 Neighboring gene predicted gene, 31420 Neighboring gene zinc finger protein 697 Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC113796, MGC117966

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphoglycerate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphoglycerate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphoglycerate dehydrogenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within L-serine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in L-serine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within L-serine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within gamma-aminobutyric acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glial cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glutamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within glycine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spinal cord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within taurine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within threonine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in myelin sheath HDA PubMed 

    General protein information

    Preferred Names
    D-3-phosphoglycerate dehydrogenase
    Names
    3-phosphoglycerate dehyrogenase
    NP_058662.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016966.3NP_058662.2  D-3-phosphoglycerate dehydrogenase

      See identical proteins and their annotated locations for NP_058662.2

      Status: VALIDATED

      Source sequence(s)
      AK076815, AW545294, BY290664
      Consensus CDS
      CCDS17663.1
      UniProtKB/Swiss-Prot
      Q61753
      Related
      ENSMUSP00000064755.6, ENSMUST00000065793.12
      Conserved Domains (2) summary
      PRK13581
      Location:8490
      PRK13581; D-3-phosphoglycerate dehydrogenase; Provisional
      cd12173
      Location:8310
      PGDH_4; Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      98220487..98247285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center