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    RABGAP1 RAB GTPase activating protein 1 [ Homo sapiens (human) ]

    Gene ID: 23637, updated on 7-Jul-2024

    Summary

    Official Symbol
    RABGAP1provided by HGNC
    Official Full Name
    RAB GTPase activating protein 1provided by HGNC
    Primary source
    HGNC:HGNC:17155
    See related
    Ensembl:ENSG00000011454 MIM:615882; AllianceGenome:HGNC:17155
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GAPCENA; TBC1D11
    Summary
    Enables GTPase activator activity and small GTPase binding activity. Involved in regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thyroid (RPKM 21.8), brain (RPKM 18.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RABGAP1 in Genome Data Viewer
    Location:
    9q33.2-q33.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (122931671..123104866)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (135128522..135302077)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (125703299..125867145)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28929 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:125677135-125677892 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125683768-125684268 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125684269-125684769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28931 Neighboring gene uncharacterized LOC105379839 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:125703098-125703822 Neighboring gene zinc finger and BTB domain containing 6 Neighboring gene zinc finger and BTB domain containing 26 Neighboring gene RNY1 pseudogene 15 Neighboring gene ribosomal protein S25 pseudogene 8 Neighboring gene COP9 signalosome subunit 2 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:125834601-125835274 Neighboring gene G protein-coupled receptor 21 Neighboring gene Sharpr-MPRA regulatory region 8358 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28932 Neighboring gene MIR600 host gene Neighboring gene microRNA 600 Neighboring gene spermatid perinuclear RNA binding protein Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:125937073-125937784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20247 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:126030691-126031191 Neighboring gene uncharacterized LOC105376265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28936

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp586D2123

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tubulin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in regulation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in regulation of cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of microtubule associated complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    rab GTPase-activating protein 1
    Names
    GAP and centrosome-associated protein
    Rab6 GTPase activating protein, GAPCenA
    TBC1 domain family, member 11
    rab6 GTPase activating protein (GAP and centrosome-associated)
    rab6 GTPase-activating protein GAPCenA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012197.4NP_036329.3  rab GTPase-activating protein 1

      See identical proteins and their annotated locations for NP_036329.3

      Status: VALIDATED

      Source sequence(s)
      AA948302, AL365338, BC054492, BG622097
      Consensus CDS
      CCDS6848.2
      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
      Related
      ENSP00000362751.4, ENST00000373647.9
      Conserved Domains (4) summary
      smart00164
      Location:563772
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:8231047
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:307437
      DUF3694; Kinesin protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      122931671..123104866
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423130.1XP_047279086.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
    2. XM_017014567.3XP_016870056.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
      Conserved Domains (4) summary
      smart00164
      Location:563772
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:8231047
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:307437
      DUF3694; Kinesin protein
    3. XM_017014569.2XP_016870058.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
      Conserved Domains (4) summary
      smart00164
      Location:563772
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:8231047
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:307437
      DUF3694; Kinesin protein
    4. XM_017014568.2XP_016870057.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
      Conserved Domains (4) summary
      smart00164
      Location:563772
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:8231047
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:307437
      DUF3694; Kinesin protein
    5. XM_011518441.3XP_011516743.1  rab GTPase-activating protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011516743.1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
      Conserved Domains (4) summary
      smart00164
      Location:563772
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:8231047
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:307437
      DUF3694; Kinesin protein
    6. XM_011518440.4XP_011516742.1  rab GTPase-activating protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011516742.1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
      Conserved Domains (4) summary
      smart00164
      Location:563772
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:8231047
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:307437
      DUF3694; Kinesin protein
    7. XM_024447475.2XP_024303243.1  rab GTPase-activating protein 1 isoform X4

      Conserved Domains (3) summary
      smart00164
      Location:563772
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:307437
      DUF3694; Kinesin protein
    8. XM_011518444.3XP_011516746.1  rab GTPase-activating protein 1 isoform X5

      Conserved Domains (3) summary
      smart00164
      Location:563663
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:356437
      DUF3694; Kinesin protein
    9. XM_047423135.1XP_047279091.1  rab GTPase-activating protein 1 isoform X6

    10. XM_024447476.2XP_024303244.1  rab GTPase-activating protein 1 isoform X6

      Conserved Domains (3) summary
      cd01211
      Location:145273
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:307437
      DUF3694; Kinesin protein
      cl02495
      Location:563597
      RabGAP-TBC; Rab-GTPase-TBC domain
    11. XM_047423134.1XP_047279090.1  rab GTPase-activating protein 1 isoform X6

    12. XM_024447474.2XP_024303242.1  rab GTPase-activating protein 1 isoform X2

      Conserved Domains (4) summary
      smart00164
      Location:495704
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:755979
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01211
      Location:77205
      PTB_Rab6GAP; GTPase activating protein for Rab 6 Phosphotyrosine-binding (PTB) domain
      pfam12473
      Location:239369
      DUF3694; Kinesin protein
    13. XM_047423132.1XP_047279088.1  rab GTPase-activating protein 1 isoform X3

    14. XM_047423131.1XP_047279087.1  rab GTPase-activating protein 1 isoform X3

    15. XM_024447477.2XP_024303245.1  rab GTPase-activating protein 1 isoform X7

      UniProtKB/TrEMBL
      B7Z2B4
      Conserved Domains (2) summary
      pfam00566
      Location:1111
      RabGAP-TBC; Rab-GTPase-TBC domain
      NF033930
      Location:203386
      pneumo_PspA; pneumococcal surface protein A

    RNA

    1. XR_007061269.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      135128522..135302077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362577.1XP_054218552.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
    2. XM_054362574.1XP_054218549.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
    3. XM_054362576.1XP_054218551.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
    4. XM_054362585.1XP_054218560.1  rab GTPase-activating protein 1 isoform X6

    5. XM_054362578.1XP_054218553.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
    6. XM_054362575.1XP_054218550.1  rab GTPase-activating protein 1 isoform X1

      UniProtKB/Swiss-Prot
      B9A6L2, Q05CW2, Q6ZMY1, Q9HA28, Q9P0E2, Q9UG67, Q9Y3P9
    7. XM_054362582.1XP_054218557.1  rab GTPase-activating protein 1 isoform X4

    8. XM_054362583.1XP_054218558.1  rab GTPase-activating protein 1 isoform X5

    9. XM_054362586.1XP_054218561.1  rab GTPase-activating protein 1 isoform X6

    10. XM_054362584.1XP_054218559.1  rab GTPase-activating protein 1 isoform X6

    11. XM_054362579.1XP_054218554.1  rab GTPase-activating protein 1 isoform X2

    12. XM_054362581.1XP_054218556.1  rab GTPase-activating protein 1 isoform X3

    13. XM_054362580.1XP_054218555.1  rab GTPase-activating protein 1 isoform X3

    14. XM_054362587.1XP_054218562.1  rab GTPase-activating protein 1 isoform X7

      UniProtKB/TrEMBL
      B7Z2B4

    RNA

    1. XR_008487972.1 RNA Sequence