U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    NTSR2 neurotensin receptor 2 [ Homo sapiens (human) ]

    Gene ID: 23620, updated on 17-Mar-2024

    Summary

    Official Symbol
    NTSR2provided by HGNC
    Official Full Name
    neurotensin receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:8040
    See related
    Ensembl:ENSG00000169006 MIM:605538; AllianceGenome:HGNC:8040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NTR2
    Summary
    The protein encoded by this gene belongs to the G protein-coupled receptor family that activate a phosphatidylinositol-calcium second messenger system. Binding and pharmacological studies demonstrate that this receptor binds neurotensin as well as several other ligands already described for neurotensin NT1 receptor. However, unlike NT1 receptor, this gene recognizes, with high affinity, levocabastine, a histamine H1 receptor antagonist previously shown to compete with neurotensin for low-affinity binding sites in brain. These activities suggest that this receptor may be of physiological importance and that a natural agonist for the receptor may exist. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward brain (RPKM 9.3) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NTSR2 in Genome Data Viewer
    Location:
    2p25.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (11658178..11670195, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (11691322..11703339, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (11798304..11810321, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene growth regulating estrogen receptor binding 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11714607-11715107 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11718473-11719108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11719109-11719744 Neighboring gene RNA, 5S ribosomal pseudogene 85 Neighboring gene Sharpr-MPRA regulatory region 7562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11175 Neighboring gene RNA, 7SL, cytoplasmic 674, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:11738736-11738940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11756351-11756851 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:11771171-11772370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:11796533-11797486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11809762-11810298 Neighboring gene uncharacterized LOC100506405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11822031-11822671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11828037-11828536 Neighboring gene cyclin dependent kinase 8 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:11836720-11837568 Neighboring gene lipin 1 Neighboring gene uncharacterized LOC101929752

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    neurotensin receptor type 2
    Names
    NT-R-2
    levocabastine-sensitive neurotensin receptor
    neurotensin receptor, type 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012344.4NP_036476.2  neurotensin receptor type 2

      Status: REVIEWED

      Source sequence(s)
      AC106875, AC110754
      Consensus CDS
      CCDS1681.1
      UniProtKB/Swiss-Prot
      O95665, Q53QQ5, Q57Z87, Q8IY58, Q8TBH6
      Related
      ENSP00000303686.5, ENST00000306928.6
      Conserved Domains (1) summary
      cd15356
      Location:33369
      7tmA_NTSR2; neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      11658178..11670195 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005246156.4XP_005246213.1  neurotensin receptor type 2 isoform X4

      Conserved Domains (1) summary
      pfam00001
      Location:98182
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_006711877.4XP_006711940.1  neurotensin receptor type 2 isoform X3

      Conserved Domains (2) summary
      cd14964
      Location:3559
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33233
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    3. XM_006711876.5XP_006711939.1  neurotensin receptor type 2 isoform X2

      Conserved Domains (1) summary
      pfam00001
      Location:98234
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. XM_017003738.2XP_016859227.1  neurotensin receptor type 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      11691322..11703339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341228.1XP_054197203.1  neurotensin receptor type 2 isoform X4

    2. XM_054341227.1XP_054197202.1  neurotensin receptor type 2 isoform X3

    3. XM_054341226.1XP_054197201.1  neurotensin receptor type 2 isoform X2

    4. XM_054341225.1XP_054197200.1  neurotensin receptor type 2 isoform X1