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    ORC6 origin recognition complex subunit 6 [ Homo sapiens (human) ]

    Gene ID: 23594, updated on 20-Dec-2019

    Summary

    Official Symbol
    ORC6provided by HGNC
    Official Full Name
    origin recognition complex subunit 6provided by HGNC
    Primary source
    HGNC:HGNC:17151
    See related
    Ensembl:ENSG00000091651 MIM:607213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ORC6L
    Summary
    The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
    Expression
    Broad expression in testis (RPKM 6.8), bone marrow (RPKM 5.0) and 16 other tissues See more
    Orthologs

    Genomic context

    See ORC6 in Genome Data Viewer
    Location:
    16q11.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (46689656..46698394)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46723558..46732306)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RAB43 pseudogene 1 Neighboring gene VPS35 retromer complex component Neighboring gene myosin light chain kinase 3 Neighboring gene nuclear factor, erythroid 2 like 3 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA replication TAS
    Traceable Author Statement
    more info
     
    DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
     
    negative regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    membrane HDA PubMed 
    nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    origin recognition complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    origin recognition complex subunit 6

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028241.1 RefSeqGene

      Range
      5014..13749
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014321.4NP_055136.1  origin recognition complex subunit 6

      See identical proteins and their annotated locations for NP_055136.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      BC050725, BC063565
      Consensus CDS
      CCDS10722.1
      UniProtKB/Swiss-Prot
      Q9Y5N6
      UniProtKB/TrEMBL
      A0A024R6R3
      Related
      ENSP00000219097.2, ENST00000219097.7
      Conserved Domains (3) summary
      cd11583
      Location:94186
      Orc6_mid; Middle domain of the origin recognition complex subunit 6
      cd16075
      Location:199249
      ORC6_CTD; C-terminal domain of the eukaryotic origin recognition complex subunit ORC6
      pfam05460
      Location:694
      ORC6; Origin recognition complex subunit 6 (ORC6)

    RNA

    1. NR_037620.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most [supported/expected] translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC007225, BC050725, BC063565, BG822640

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

      Range
      46689656..46698394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522978.3XP_011521280.1  origin recognition complex subunit 6 isoform X1

      Conserved Domains (2) summary
      pfam05460
      Location:694
      ORC6; Origin recognition complex subunit 6 (ORC6)
      cl21687
      Location:94150
      Orc6_mid; Middle domain of the origin recognition complex subunit 6
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