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    HEBP2 heme binding protein 2 [ Homo sapiens (human) ]

    Gene ID: 23593, updated on 17-Jun-2024

    Summary

    Official Symbol
    HEBP2provided by HGNC
    Official Full Name
    heme binding protein 2provided by HGNC
    Primary source
    HGNC:HGNC:15716
    See related
    Ensembl:ENSG00000051620 MIM:605825; AllianceGenome:HGNC:15716
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP23; SOUL; C6orf34; C6ORF34B
    Summary
    The protein encoded by this gene is found predominately in the cytoplasm, where it plays a role in the collapse of mitochondrial membrane potential (MMP) prior to necrotic cell death. The encoded protein enhances outer and inner mitochondrial membrane permeabilization, especially under conditions of oxidative stress. [provided by RefSeq, May 2016]
    Expression
    Ubiquitous expression in fat (RPKM 80.4), prostate (RPKM 27.2) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See HEBP2 in Genome Data Viewer
    Location:
    6q24.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (138403531..138422197)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (139592015..139610681)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (138724668..138743334)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ARFGEF family member 3 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90581 Neighboring gene prostate and breast cancer overexpressed 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138608085-138608584 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:138650317-138651290 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:138651291-138652264 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:138652315-138653064 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:138653065-138653812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138655517-138656120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138656121-138656722 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138698741-138699245 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:138725096-138725616 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17595 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:138724054-138724574 Neighboring gene MARCKS like 1 pseudogene 2 Neighboring gene small integral membrane protein 28 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138751321-138751822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138751823-138752322 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:138762212-138762399 Neighboring gene microRNA 3145 Neighboring gene NHS like 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:138807227-138807846 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90625 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_90641 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:138893284-138894040 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138897819-138898319 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:138912362-138912862 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:138912863-138913363 Neighboring gene Sharpr-MPRA regulatory region 8531 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25159 Neighboring gene MTCH1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of heme binding protein 2 (HEBP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of heme binding protein 2 (HEBP2; SOUL) in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1244

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heme-binding protein 2
    Names
    placental protein 23

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050594.1 RefSeqGene

      Range
      5025..22999
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001326380.2NP_001313309.1  heme-binding protein 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL031003, AL391669
    2. NM_001326381.2NP_001313310.1  heme-binding protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL031003, AL391669
      Consensus CDS
      CCDS87448.1
      UniProtKB/TrEMBL
      Q5THN1
      Related
      ENSP00000356670.3, ENST00000367697.7
    3. NM_014320.3NP_055135.1  heme-binding protein 2 isoform 2

      See identical proteins and their annotated locations for NP_055135.1

      Status: REVIEWED

      Source sequence(s)
      AF117616, AK057928, AL391669, BF974311
      Consensus CDS
      CCDS5191.1
      UniProtKB/Swiss-Prot
      Q96P57, Q9Y5Z4
      UniProtKB/TrEMBL
      Q05DB4
      Related
      ENSP00000475750.1, ENST00000607197.6
      Conserved Domains (1) summary
      pfam04832
      Location:36195
      SOUL; SOUL heme-binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      138403531..138422197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      139592015..139610681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)