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    PDSS1 decaprenyl diphosphate synthase subunit 1 [ Homo sapiens (human) ]

    Gene ID: 23590, updated on 11-Apr-2024

    Summary

    Official Symbol
    PDSS1provided by HGNC
    Official Full Name
    decaprenyl diphosphate synthase subunit 1provided by HGNC
    Primary source
    HGNC:HGNC:17759
    See related
    Ensembl:ENSG00000148459 MIM:607429; AllianceGenome:HGNC:17759
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DPS; SPS; TPT; COQ1; TPRT; COQ1A; TPT 1; hDPS1; COQ10D2
    Summary
    The protein encoded by this gene is an enzyme that elongates the prenyl side-chain of coenzyme Q, or ubiquinone, one of the key elements in the respiratory chain. The gene product catalyzes the formation of all trans-polyprenyl pyrophosphates from isopentyl diphosphate in the assembly of polyisoprenoid side chains, the first step in coenzyme Q biosynthesis. The protein may be peripherally associated with the inner mitochondrial membrane, though no transit peptide has been definitively identified to date. Defects in this gene are a cause of coenzyme Q10 deficiency. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in duodenum (RPKM 4.4), small intestine (RPKM 3.8) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10p12.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (26697701..26746798)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (26722732..26768706)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (26986630..27035727)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 238 member B Neighboring gene selenoprotein O like, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:26986797-26987685 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3172 Neighboring gene abl interactor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3175 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:27070945-27071686 Neighboring gene small nucleolar RNA SNORA57 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2239 Neighboring gene RNA, U6 small nuclear 946, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of prenyl (decaprenyl) diphosphate synthase, subunit 1 (PDSS1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC70953

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to all-trans-decaprenyl-diphosphate synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables all-trans-nonaprenyl-diphosphate synthase (geranyl-diphosphate specific) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables prenyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in isoprenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquinone biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquinone biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of heterotetrameric polyprenyl diphosphate synthase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    part_of transferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    all trans-polyprenyl-diphosphate synthase PDSS1
    Names
    all-trans-decaprenyl-diphosphate synthase subunit 1
    coenzyme Q1 homolog
    decaprenyl pyrophosphate synthase subunit 1
    polyprenyl pyrophosphate synthetase
    prenyl (decaprenyl) diphosphate synthase, subunit 1
    solanesyl-diphosphate synthase subunit 1
    subunit 1 of decaprenyl diphosphate synthase
    trans-prenyltransferase (TPT)
    trans-prenyltransferase 1
    NP_001308907.1
    NP_001308908.1
    NP_055132.2
    XP_011517739.1
    XP_016871500.1
    XP_024303690.1
    XP_047280889.1
    XP_054221350.1
    XP_054221351.1
    XP_054221352.1
    XP_054221353.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008972.2 RefSeqGene

      Range
      5036..54133
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001321978.2NP_001308907.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AK024802, AL390961, BC063635
      UniProtKB/Swiss-Prot
      Q5T2R2
      Conserved Domains (1) summary
      cd00685
      Location:121277
      Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
    2. NM_001321979.2NP_001308908.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL390961
      Conserved Domains (1) summary
      cl00210
      Location:1243
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
    3. NM_014317.5NP_055132.2  all trans-polyprenyl-diphosphate synthase PDSS1 isoform 1

      See identical proteins and their annotated locations for NP_055132.2

      Status: REVIEWED

      Source sequence(s)
      AK024802, BC049211
      Consensus CDS
      CCDS31168.1
      UniProtKB/Swiss-Prot
      Q53F75, Q5T2R2, Q6P473, Q86WQ8, Q9Y2W5
      Related
      ENSP00000365388.5, ENST00000376215.10
      Conserved Domains (2) summary
      PLN02890
      Location:6415
      PLN02890; geranyl diphosphate synthase
      cl00210
      Location:102413
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      26697701..26746798
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447922.2XP_024303690.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform X1

      Conserved Domains (1) summary
      cd00685
      Location:121343
      Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
    2. XM_047424933.1XP_047280889.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform X4

    3. XM_017016011.3XP_016871500.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform X2

    4. XM_011519437.4XP_011517739.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform X3

      Conserved Domains (1) summary
      cl00210
      Location:2290
      Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      26722732..26768706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365375.1XP_054221350.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform X1

    2. XM_054365378.1XP_054221353.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform X4

    3. XM_054365376.1XP_054221351.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform X2

    4. XM_054365377.1XP_054221352.1  all trans-polyprenyl-diphosphate synthase PDSS1 isoform X3