Format

Send to:

Choose Destination
    • Showing Current items.

    Setd2 SET domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 235626, updated on 20-Jul-2021

    Summary

    Official Symbol
    Setd2provided by MGI
    Official Full Name
    SET domain containing 2provided by MGI
    Primary source
    MGI:MGI:1918177
    See related
    Ensembl:ENSMUSG00000044791
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KMT3; KMT3A; BC031601; 4921524K10Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 11.9), CNS E14 (RPKM 11.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Setd2 in Genome Data Viewer
    Location:
    9; 9 F2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110361368..110447701)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110532500..110618633)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (110435101..110521137)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene kelch-like 18 Neighboring gene kinesin family member 9 Neighboring gene neurotrophin receptor associated death domain Neighboring gene neurobeachin-like 2 Neighboring gene microRNA 8107

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables alpha-tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone methyltransferase activity (H3-K36 specific) IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone methyltransferase activity (H3-K36 specific) ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell migration involved in vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within coronary vasculature morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in defense response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic placenta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in endodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K36 dimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within histone H3-K36 methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within histone H3-K36 trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K36 trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in histone H3-K36 trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in histone lysine methylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesoderm morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule cytoskeleton organization involved in mitosis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mismatch repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within morphogenesis of a branching structure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within neural tube closure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nucleosome organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine monomethylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within peptidyl-lysine trimethylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine trimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pericardium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization to chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to type I interferon ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within stem cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transcription elongation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase SETD2
    Names
    SET domain-containing protein 2
    lysine N-methyltransferase 3A
    protein-lysine N-methyltransferase SETD2
    NP_001074809.2
    XP_006512151.1
    XP_006512154.1
    XP_006512155.1
    XP_036010808.1
    XP_036010809.1
    XP_036010810.1
    XP_036010811.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081340.2NP_001074809.2  histone-lysine N-methyltransferase SETD2

      See identical proteins and their annotated locations for NP_001074809.2

      Status: VALIDATED

      Source sequence(s)
      AC132103, AK173246, BE953532, CB246241, CB520818, CX564178
      Consensus CDS
      CCDS40781.2
      UniProtKB/Swiss-Prot
      E9Q5F9
      Related
      ENSMUSP00000116313.3, ENSMUST00000153838.8
      Conserved Domains (6) summary
      pfam05279
      Location:19142096
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      smart00570
      Location:14691523
      AWS; associated with SET domains
      smart00317
      Location:15241647
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:16481664
      PostSET; Cysteine-rich motif following a subset of SET domains
      pfam00397
      Location:23642393
      WW; WW domain
      pfam08236
      Location:24422521
      SRI; SRI (Set2 Rpb1 interacting) domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110361368..110447701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154915.1XP_036010808.1  histone-lysine N-methyltransferase SETD2 isoform X1

    2. XM_036154916.1XP_036010809.1  histone-lysine N-methyltransferase SETD2 isoform X3

      Conserved Domains (4) summary
      smart00570
      Location:14831537
      AWS; associated with SET domains
      cd19172
      Location:15371678
      SET_SETD2; SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins
      pfam00397
      Location:23772406
      WW; WW domain
      pfam08236
      Location:24532541
      SRI; SRI (Set2 Rpb1 interacting) domain
    3. XM_036154917.1XP_036010810.1  histone-lysine N-methyltransferase SETD2 isoform X4

      Conserved Domains (4) summary
      smart00570
      Location:14781532
      AWS; associated with SET domains
      cd19172
      Location:15321673
      SET_SETD2; SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins
      pfam00397
      Location:23732402
      WW; WW domain
      pfam08236
      Location:24492537
      SRI; SRI (Set2 Rpb1 interacting) domain
    4. XM_006512088.5XP_006512151.1  histone-lysine N-methyltransferase SETD2 isoform X2

      Conserved Domains (5) summary
      pfam05279
      Location:19272109
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      smart00570
      Location:14821536
      AWS; associated with SET domains
      pfam00397
      Location:23772406
      WW; WW domain
      pfam08236
      Location:24552542
      SRI; SRI (Set2 Rpb1 interacting) domain
      cd19172
      Location:15361677
      SET_SETD2; SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins
    5. XM_006512091.5XP_006512154.1  histone-lysine N-methyltransferase SETD2 isoform X5

      Conserved Domains (5) summary
      pfam05279
      Location:19222104
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      smart00570
      Location:14771531
      AWS; associated with SET domains
      pfam00397
      Location:23722401
      WW; WW domain
      pfam08236
      Location:24502537
      SRI; SRI (Set2 Rpb1 interacting) domain
      cd19172
      Location:15311672
      SET_SETD2; SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins
    6. XM_006512092.5XP_006512155.1  histone-lysine N-methyltransferase SETD2 isoform X6

      Conserved Domains (5) summary
      pfam05279
      Location:19192101
      Asp-B-Hydro_N; Aspartyl beta-hydroxylase N-terminal region
      smart00570
      Location:14741528
      AWS; associated with SET domains
      pfam00397
      Location:23692398
      WW; WW domain
      pfam08236
      Location:24472534
      SRI; SRI (Set2 Rpb1 interacting) domain
      cd19172
      Location:15281669
      SET_SETD2; SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins
    7. XM_036154918.1XP_036010811.1  histone-lysine N-methyltransferase SETD2 isoform X7

    RNA

    1. XR_004935430.1 RNA Sequence

      Related
      ENSMUST00000196814.5
    2. XR_004935431.1 RNA Sequence

    3. XR_004935429.1 RNA Sequence

    Support Center