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    Scap SREBF chaperone [ Mus musculus (house mouse) ]

    Gene ID: 235623, updated on 22-Aug-2021

    Summary

    Official Symbol
    Scapprovided by MGI
    Official Full Name
    SREBF chaperoneprovided by MGI
    Primary source
    MGI:MGI:2135958
    See related
    Ensembl:ENSMUSG00000032485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0199; 9530044G19
    Expression
    Ubiquitous expression in ovary adult (RPKM 50.5), adrenal adult (RPKM 43.4) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Scap in Genome Data Viewer
    Location:
    9 F2; 9 59.91 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110162356..110214017)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110333288..110384949)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (110235797..110287450)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39429 Neighboring gene microRNA 6236 Neighboring gene tropomyosin beta chain pseudogene Neighboring gene elongator acetyltransferase complex subunit 6 Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene neutrophilic granule protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Transgenic (1) 
    • Gene trapped (1) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables sterol binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sterol regulatory element-binding protein cleavage-activating protein
    Names
    SREBP cleavage activating protein
    Sreb cleavage-activating protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001144.3NP_001001144.2  sterol regulatory element-binding protein cleavage-activating protein

      See identical proteins and their annotated locations for NP_001001144.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      BC070437, BC072633, BM250223
      Consensus CDS
      CCDS23564.1
      UniProtKB/Swiss-Prot
      Q6GQT6
      Related
      ENSMUSP00000095953.4, ENSMUST00000098350.10
      Conserved Domains (5) summary
      smart00320
      Location:771802
      WD40; WD40 repeats
      TIGR00917
      Location:11466
      2A060601; Niemann-Pick C type protein family
      sd00039
      Location:957998
      7WD40; WD40 repeat [structural motif]
      pfam12349
      Location:308454
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      cl29593
      Location:10651232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001103162.2NP_001096632.1  sterol regulatory element-binding protein cleavage-activating protein

      See identical proteins and their annotated locations for NP_001096632.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK150275, BC070437, BM250223, BY311416
      Consensus CDS
      CCDS23564.1
      UniProtKB/Swiss-Prot
      Q6GQT6
      Conserved Domains (5) summary
      smart00320
      Location:771802
      WD40; WD40 repeats
      TIGR00917
      Location:11466
      2A060601; Niemann-Pick C type protein family
      sd00039
      Location:957998
      7WD40; WD40 repeat [structural motif]
      pfam12349
      Location:308454
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      cl29593
      Location:10651232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      110162356..110214017
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512083.3XP_006512146.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

      See identical proteins and their annotated locations for XP_006512146.1

      UniProtKB/Swiss-Prot
      Q6GQT6
      Conserved Domains (5) summary
      smart00320
      Location:771802
      WD40; WD40 repeats
      TIGR00917
      Location:11466
      2A060601; Niemann-Pick C type protein family
      sd00039
      Location:957998
      7WD40; WD40 repeat [structural motif]
      pfam12349
      Location:308454
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      cl29593
      Location:10651232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. XM_006512084.4XP_006512147.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

      See identical proteins and their annotated locations for XP_006512147.1

      UniProtKB/Swiss-Prot
      Q6GQT6
      Conserved Domains (5) summary
      smart00320
      Location:771802
      WD40; WD40 repeats
      TIGR00917
      Location:11466
      2A060601; Niemann-Pick C type protein family
      sd00039
      Location:957998
      7WD40; WD40 repeat [structural motif]
      pfam12349
      Location:308454
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      cl29593
      Location:10651232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. XM_006512085.4XP_006512148.1  sterol regulatory element-binding protein cleavage-activating protein isoform X1

      See identical proteins and their annotated locations for XP_006512148.1

      UniProtKB/Swiss-Prot
      Q6GQT6
      Conserved Domains (5) summary
      smart00320
      Location:771802
      WD40; WD40 repeats
      TIGR00917
      Location:11466
      2A060601; Niemann-Pick C type protein family
      sd00039
      Location:957998
      7WD40; WD40 repeat [structural motif]
      pfam12349
      Location:308454
      Sterol-sensing; Sterol-sensing domain of SREBP cleavage-activation
      cl29593
      Location:10651232
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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