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    Atp2c1 ATPase, Ca++-sequestering [ Mus musculus (house mouse) ]

    Gene ID: 235574, updated on 2-Mar-2019

    Summary

    Official Symbol
    Atp2c1provided by MGI
    Official Full Name
    ATPase, Ca++-sequesteringprovided by MGI
    Primary source
    MGI:MGI:1889008
    See related
    Ensembl:ENSMUSG00000032570
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HHD; BCPM; SPCA; pmr1; ATP2C1A; AW061228; 1700121J11Rik; D930003G21Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 19.7), frontal lobe adult (RPKM 16.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Atp2c1 in Genome Data Viewer
    Location:
    9; 9 F1
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (105411362..105521257, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (105313692..105397447, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 2 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 11 Neighboring gene asteroid homolog 1 Neighboring gene predicted gene, 40564 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 2 pseudogene Neighboring gene predicted gene 5621

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Clone Names

    • MGC58010

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-transporting ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium-transporting ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-transporting ATPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    manganese-transporting ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    manganese-transporting ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    proton-exporting ATPase activity, phosphorylative mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    Golgi calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cellular calcium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular manganese ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    epidermis development ISO
    Inferred from Sequence Orthology
    more info
     
    ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    manganese ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    secretory granule ISO
    Inferred from Sequence Orthology
    more info
     
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    calcium-transporting ATPase type 2C member 1
    Names
    ATP-dependent Ca(2+) pump PMR1
    ATPase 2C1
    ATPase, Ca++ transporting, type 2C, member 1
    NP_001240760.1
    NP_001240763.1
    NP_001240765.1
    NP_778190.3
    XP_006511773.1
    XP_006511774.1
    XP_006511775.1
    XP_006511777.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253831.1NP_001240760.1  calcium-transporting ATPase type 2C member 1 isoform 1

      See identical proteins and their annotated locations for NP_001240760.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK133703, AK163049, AK173154, BC043091
      Consensus CDS
      CCDS57698.1
      UniProtKB/Swiss-Prot
      Q80XR2
      UniProtKB/TrEMBL
      Q3UZR5, Q69ZL4
      Related
      ENSMUSP00000082220.6, ENSMUST00000085133.12
      Conserved Domains (6) summary
      TIGR01522
      Location:57936
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      COG4087
      Location:589712
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:152372
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:759931
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:60128
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:443526
      Cation_ATPase; Cation transport ATPase (P-type)
    2. NM_001253834.1NP_001240763.1  calcium-transporting ATPase type 2C member 1 isoform 2

      See identical proteins and their annotated locations for NP_001240763.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' end which results in the use of an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AJ551270, AK163049, AK173154, BC043091, BU611728
      Consensus CDS
      CCDS40752.1
      UniProtKB/Swiss-Prot
      Q80XR2
      UniProtKB/TrEMBL
      Q69ZL4
      Related
      ENSMUSP00000108177.2, ENSMUST00000112558.9
      Conserved Domains (6) summary
      TIGR01522
      Location:23902
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      COG4087
      Location:610678
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:118338
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:725897
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:2694
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:409492
      Cation_ATPase; Cation transport ATPase (P-type)
    3. NM_001253836.1NP_001240765.1  calcium-transporting ATPase type 2C member 1 isoform 3

      See identical proteins and their annotated locations for NP_001240765.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has a multiple differences, compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
      Source sequence(s)
      AK028393, BU611728, BU754887
      Consensus CDS
      CCDS57697.1
      UniProtKB/TrEMBL
      Q8BMS7
      Related
      ENSMUSP00000129617.2, ENSMUST00000163879.8
      Conserved Domains (4) summary
      COG4087
      Location:594662
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:102322
      E1-E2_ATPase; E1-E2 ATPase
      pfam00690
      Location:1078
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:393476
      Cation_ATPase; Cation transport ATPase (P-type)
    4. NM_001359822.1NP_001346751.1  calcium-transporting ATPase type 2C member 1 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has a different 5' end which results in the use of an alternate start codon, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC113016, AC117679, BC043091
      Conserved Domains (1) summary
      cd02085
      Location:58899
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
    5. NM_001359823.1NP_001346752.1  calcium-transporting ATPase type 2C member 1 isoform 5

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has a different 5' end which causes translation initiation at a downstream start codon, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AC113016, AC117679, BC043091
      Conserved Domains (1) summary
      cd02085
      Location:38879
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
    6. NM_175025.4NP_778190.3  calcium-transporting ATPase type 2C member 1 isoform 2

      See identical proteins and their annotated locations for NP_778190.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has a different 5' end which results in the use of an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AK173154, BC043091, BC043706, BU611728
      Consensus CDS
      CCDS40752.1
      UniProtKB/Swiss-Prot
      Q80XR2
      UniProtKB/TrEMBL
      Q69ZL4
      Related
      ENSMUSP00000039103.7, ENSMUST00000038118.14
      Conserved Domains (6) summary
      TIGR01522
      Location:23902
      ATPase-IIA2_Ca; golgi membrane calcium-translocating P-type ATPase
      COG4087
      Location:610678
      COG4087; Soluble P-type ATPase [General function prediction only]
      pfam00122
      Location:118338
      E1-E2_ATPase; E1-E2 ATPase
      pfam00689
      Location:725897
      Cation_ATPase_C; Cation transporting ATPase, C-terminus
      pfam00690
      Location:2694
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam13246
      Location:409492
      Cation_ATPase; Cation transport ATPase (P-type)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      105411362..105521257 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511712.3XP_006511775.1  calcium-transporting ATPase type 2C member 1 isoform X1

      See identical proteins and their annotated locations for XP_006511775.1

      Conserved Domains (1) summary
      cd02085
      Location:58899
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
    2. XM_006511714.3XP_006511777.1  calcium-transporting ATPase type 2C member 1 isoform X2

      Related
      ENSMUSP00000135802.1, ENSMUST00000177293.7
      Conserved Domains (1) summary
      cd02085
      Location:38879
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
    3. XM_006511710.2XP_006511773.1  calcium-transporting ATPase type 2C member 1 isoform X1

      Conserved Domains (1) summary
      cd02085
      Location:58899
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
    4. XM_006511711.3XP_006511774.1  calcium-transporting ATPase type 2C member 1 isoform X1

      See identical proteins and their annotated locations for XP_006511774.1

      Related
      ENSMUSP00000135646.1, ENSMUST00000177074.7
      Conserved Domains (1) summary
      cd02085
      Location:58899
      P-type_ATPase_SPCA; golgi-associated secretory pathway Ca(2+) transport ATPases, similar to human ATPase secretory pathway Ca(2+) transporting 1/hSPCA1 and Saccharomyces cerevisiae Ca(2+)/Mn(2+)-transporting P-type ATPase, Pmr1p
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