Format

Send to:

Choose Destination
    • Showing Current items.

    Topbp1 topoisomerase (DNA) II binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 235559, updated on 23-Jun-2021

    Summary

    Official Symbol
    Topbp1provided by MGI
    Official Full Name
    topoisomerase (DNA) II binding protein 1provided by MGI
    Primary source
    MGI:MGI:1920018
    See related
    Ensembl:ENSMUSG00000032555
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI256758; mKIAA0259; 1110031N14Rik; 2810429C13Rik; D430026L04Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 24.0), liver E14 (RPKM 19.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Topbp1 in Genome Data Viewer
    Location:
    9; 9 F1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (103182351..103227627)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (103305167..103350428)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (103207657..103252758)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1300017J02 gene Neighboring gene predicted gene, 53542 Neighboring gene predicted gene, 31701 Neighboring gene carnitine deficiency-associated gene expressed in ventricle 3 Neighboring gene RIKEN cDNA 5830418P13 gene Neighboring gene beaded filament structural protein 2, phakinin

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in DNA replication initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic DNA replication checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic G2 DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within reciprocal meiotic recombination ISA
    Inferred from Sequence Alignment
    more info
    PubMed 
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA topoisomerase 2-binding protein 1
    Names
    DNA topoisomerase II-beta-binding protein 1
    DNA topoisomerase II-binding protein 1
    topoisomerase (DNA) II beta binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176979.5NP_795953.2  DNA topoisomerase 2-binding protein 1

      See identical proteins and their annotated locations for NP_795953.2

      Status: PROVISIONAL

      Source sequence(s)
      AC122747
      Consensus CDS
      CCDS23453.1
      UniProtKB/Swiss-Prot
      Q6ZQF0
      Related
      ENSMUSP00000035164.4, ENSMUST00000035164.10
      Conserved Domains (10) summary
      PHA01732
      Location:12021271
      PHA01732; proline-rich protein
      PRK13108
      Location:11271248
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      cd17718
      Location:352433
      BRCT_TopBP1_rpt3; third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17727
      Location:907981
      BRCT_TopBP1_rpt6; sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17728
      Location:13921470
      BRCT_TopBP1_rpt8; eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1
      cd17731
      Location:198274
      BRCT_TopBP1_rpt2_like; second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17737
      Location:108179
      BRCT_TopBP1_rpt1; first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17738
      Location:12631337
      BRCT_TopBP1_rpt7; seventh BRCT domain of DNA topoisomerase 2-binding protein 1
      cd17749
      Location:556639
      BRCT_TopBP1_rpt4; fourth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd18434
      Location:648736
      BRCT_TopBP1_rpt5; fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      103182351..103227627
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511706.5XP_006511769.3  DNA topoisomerase 2-binding protein 1 isoform X1

      Conserved Domains (10) summary
      PHA01732
      Location:12281297
      PHA01732; proline-rich protein
      cd17718
      Location:427508
      BRCT_TopBP1_rpt3; third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17727
      Location:9821052
      BRCT_TopBP1_rpt6; sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17728
      Location:14181496
      BRCT_TopBP1_rpt8; eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1
      cd17731
      Location:273349
      BRCT_TopBP1_rpt2_like; second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17737
      Location:183254
      BRCT_TopBP1_rpt1; first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17738
      Location:12891363
      BRCT_TopBP1_rpt7; seventh BRCT domain of DNA topoisomerase 2-binding protein 1
      cd17749
      Location:631714
      BRCT_TopBP1_rpt4; fourth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd18434
      Location:723811
      BRCT_TopBP1_rpt5; fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      NF033804
      Location:11591272
      Streccoc_I_II; antigen I/II family LPXTG-anchored adhesin
    2. XM_006511707.4XP_006511770.1  DNA topoisomerase 2-binding protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006511770.1

      UniProtKB/Swiss-Prot
      Q6ZQF0
      Conserved Domains (10) summary
      PHA01732
      Location:12021271
      PHA01732; proline-rich protein
      PRK13108
      Location:11271248
      PRK13108; prolipoprotein diacylglyceryl transferase; Reviewed
      cd17718
      Location:352433
      BRCT_TopBP1_rpt3; third BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17727
      Location:907981
      BRCT_TopBP1_rpt6; sixth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17728
      Location:13921470
      BRCT_TopBP1_rpt8; eighth (C-terminal) BRCT domain of DNA topoisomerase 2-binding protein 1
      cd17731
      Location:198274
      BRCT_TopBP1_rpt2_like; second BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17737
      Location:108179
      BRCT_TopBP1_rpt1; first BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd17738
      Location:12631337
      BRCT_TopBP1_rpt7; seventh BRCT domain of DNA topoisomerase 2-binding protein 1
      cd17749
      Location:556639
      BRCT_TopBP1_rpt4; fourth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
      cd18434
      Location:648736
      BRCT_TopBP1_rpt5; fifth BRCT domain of DNA topoisomerase 2-binding protein 1 (TopBP1) and similar proteins
    Support Center