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    Gtf2a2 general transcription factor II A, 2 [ Mus musculus (house mouse) ]

    Gene ID: 235459, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gtf2a2provided by MGI
    Official Full Name
    general transcription factor II A, 2provided by MGI
    Primary source
    MGI:MGI:1933289
    See related
    Ensembl:ENSMUSG00000033543
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TfI; 12kD; TfIIg; Tfiia2; TFIIA-gamma
    Expression
    Ubiquitous expression in testis adult (RPKM 12.1), liver E14 (RPKM 8.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Gtf2a2 in Genome Data Viewer
    Location:
    9; 9 D
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69919830..69930148)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70012548..70022866)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (69860357..69870654)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31587 Neighboring gene BCL2/adenovirus E1B interacting protein 2 Neighboring gene glucosaminyl (N-acetyl) transferase 3, mucin type Neighboring gene predicted gene, 39369

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of transcription factor TFIIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of transcription factor TFIIA complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription factor TFIID complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transcription initiation factor IIA subunit 2
    Names
    general transcription factor IIA, 2 (12kD subunit)
    transcription initiation factor IIA gamma chain

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039519.2NP_001034608.1  transcription initiation factor IIA subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_001034608.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK165466, BB842876, BG088284, CR514895
      Consensus CDS
      CCDS52851.1
      UniProtKB/Swiss-Prot
      Q80ZM7
      UniProtKB/TrEMBL
      Q3TE88, Q3TN86
      Related
      ENSMUSP00000113501.2, ENSMUST00000118198.8
      Conserved Domains (1) summary
      COG5123
      Location:3103
      TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
    2. NM_001282083.1NP_001269012.1  transcription initiation factor IIA subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_001269012.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AK050621, AK165466, BB842876, BG088284, CR514895
      Consensus CDS
      CCDS52851.1
      UniProtKB/Swiss-Prot
      Q80ZM7
      UniProtKB/TrEMBL
      Q3TE88, Q3TN86
      Related
      ENSMUSP00000113697.2, ENSMUST00000119413.8
      Conserved Domains (1) summary
      COG5123
      Location:3103
      TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]
    3. NM_001282084.1NP_001269013.1  transcription initiation factor IIA subunit 2 isoform 2

      See identical proteins and their annotated locations for NP_001269013.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an exon in the internal coding region, which leads to a translational frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK165466, BB842876, BG088284, CR514895
      Consensus CDS
      CCDS72269.1
      UniProtKB/TrEMBL
      D3Z7C2, Q3TN86
      Related
      ENSMUSP00000113061.2, ENSMUST00000119905.8
      Conserved Domains (1) summary
      pfam02268
      Location:349
      TFIIA_gamma_N; Transcription initiation factor IIA, gamma subunit, helical domain

    RNA

    1. NR_104093.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK165466, BB842876, BC028551, CR514895
      Related
      ENSMUST00000116552.8

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      69919830..69930148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511116.2XP_006511179.1  transcription initiation factor IIA subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006511179.1

      UniProtKB/Swiss-Prot
      Q80ZM7
      UniProtKB/TrEMBL
      Q3TE88
      Conserved Domains (1) summary
      COG5123
      Location:3103
      TOA2; Transcription initiation factor IIA, gamma subunit [Transcription]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_199151.1: Suppressed sequence

      Description
      NM_199151.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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