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    Kank2 KN motif and ankyrin repeat domains 2 [ Mus musculus (house mouse) ]

    Gene ID: 235041, updated on 23-Jun-2021

    Summary

    Official Symbol
    Kank2provided by MGI
    Official Full Name
    KN motif and ankyrin repeat domains 2provided by MGI
    Primary source
    MGI:MGI:2384568
    See related
    Ensembl:ENSMUSG00000032194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ankr; Ankrd25; AI504612; BC010245
    Expression
    Broad expression in ovary adult (RPKM 63.8), lung adult (RPKM 50.9) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kank2 in Genome Data Viewer
    Location:
    9; 9 A3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21678069..21709842, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21766773..21798546, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (21571217..21602990, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor Neighboring gene SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae) Neighboring gene dedicator of cytokinesis 6 Neighboring gene predicted gene, 39305 Neighboring gene microRNA 7083

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7734, MGC12143

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glomerular visceral epithelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glomerular visceral epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in kidney epithelium development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of intracellular estrogen receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of programmed cell death ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of vitamin D receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in negative regulation of vitamin D receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of Rho protein signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    KN motif and ankyrin repeat domain-containing protein 2
    Names
    ankyrin repeat domain 25
    ankyrin repeat domain-containing protein 25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145611.4NP_663586.3  KN motif and ankyrin repeat domain-containing protein 2

      See identical proteins and their annotated locations for NP_663586.3

      Status: VALIDATED

      Source sequence(s)
      AC161371, AK049288, BB517655
      Consensus CDS
      CCDS22911.1
      UniProtKB/Swiss-Prot
      Q8BX02
      Related
      ENSMUSP00000034717.6, ENSMUST00000034717.7
      Conserved Domains (6) summary
      cd00204
      Location:653784
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12075
      Location:3169
      KN_motif; KN motif
      pfam12796
      Location:663761
      Ank_2; Ankyrin repeats (3 copies)
      pfam13637
      Location:634679
      Ank_4; Ankyrin repeats (many copies)
      pfam13857
      Location:750805
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:731761
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21678069..21709842 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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