Format

Send to:

Choose Destination
    • Showing Current items.

    Med17 mediator complex subunit 17 [ Mus musculus (house mouse) ]

    Gene ID: 234959, updated on 2-Oct-2018

    Summary

    Official Symbol
    Med17provided by MGI
    Official Full Name
    mediator complex subunit 17provided by MGI
    Primary source
    MGI:MGI:2182585
    See related
    Ensembl:ENSMUSG00000031935 Vega:OTTMUSG00000062253
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    77kDa; Crsp6; Trap80; C330002H14Rik
    Expression
    Ubiquitous expression in placenta adult (RPKM 6.0), ovary adult (RPKM 5.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Med17 in Genome Data Viewer
    Location:
    9; 9 A2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (15260351..15281483, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (15064795..15084311, complement)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39293 Neighboring gene V-set and transmembrane domain containing 5 Neighboring gene RIKEN cDNA 4931406C07 gene Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D Neighboring gene predicted gene, 25500

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    androgen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular steroid hormone receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription initiation from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mediator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mediator complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 17
    Names
    CRSP complex subunit 6
    cofactor required for Sp1 transcriptional activation, subunit 6 (77kD)
    thyroid hormone receptor-associated protein complex 80 kDa component

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364533.1NP_001351462.1  mediator of RNA polymerase II transcription subunit 17 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154296
      Conserved Domains (1) summary
      pfam10156
      Location:123396
      Med17; Subunit 17 of Mediator complex
    2. NM_144933.2NP_659182.1  mediator of RNA polymerase II transcription subunit 17 isoform 1

      See identical proteins and their annotated locations for NP_659182.1

      Status: VALIDATED

      Source sequence(s)
      BC020185, CJ078373
      Consensus CDS
      CCDS22834.1
      UniProtKB/Swiss-Prot
      Q8VCD5
      Related
      ENSMUSP00000034411.8, OTTMUSP00000078726, ENSMUST00000034411.9
      Conserved Domains (1) summary
      pfam10156
      Location:123396
      Med17; Subunit 17 of Mediator complex

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      15260351..15281483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510158.3XP_006510221.1  mediator of RNA polymerase II transcription subunit 17 isoform X2

      Conserved Domains (1) summary
      pfam10156
      Location:50316
      Med17; Subunit 17 of Mediator complex
    2. XM_006510157.3XP_006510220.1  mediator of RNA polymerase II transcription subunit 17 isoform X1

      Conserved Domains (1) summary
      pfam10156
      Location:123396
      Med17; Subunit 17 of Mediator complex
    Support Center