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    Rfwd3 ring finger and WD repeat domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 234736, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rfwd3provided by MGI
    Official Full Name
    ring finger and WD repeat domain 3provided by MGI
    Primary source
    MGI:MGI:2384584
    See related
    Ensembl:ENSMUSG00000033596
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BC027246
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.9), placenta adult (RPKM 16.6) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rfwd3 in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111997576..112026854, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111270944..111300222, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (113794844..113824122, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene predicted gene, 53455 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene mixed lineage kinase domain-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC27888

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chromosome breakage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic G1 DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RFWD3
    Names
    RING finger and WD repeat domain-containing protein 3
    RING finger protein 201
    RING-type E3 ubiquitin transferase RFWD3
    NP_666330.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146218.4NP_666330.2  E3 ubiquitin-protein ligase RFWD3

      See identical proteins and their annotated locations for NP_666330.2

      Status: PROVISIONAL

      Source sequence(s)
      AC163625
      Consensus CDS
      CCDS22672.1
      UniProtKB/Swiss-Prot
      Q8CIK8
      Related
      ENSMUSP00000043780.5, ENSMUST00000038739.5
      Conserved Domains (4) summary
      COG2319
      Location:486626
      WD40; WD40 repeat [General function prediction only]
      cd00162
      Location:287334
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      sd00039
      Location:501537
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:451571
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111997576..112026854 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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