Format

Send to:

Choose Destination
    • Showing Current items.

    Rfwd3 ring finger and WD repeat domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 234736, updated on 2-Oct-2018

    Summary

    Official Symbol
    Rfwd3provided by MGI
    Official Full Name
    ring finger and WD repeat domain 3provided by MGI
    Primary source
    MGI:MGI:2384584
    See related
    Ensembl:ENSMUSG00000033596 Vega:OTTMUSG00000061896
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BC027246
    Expression
    Ubiquitous expression in liver E14 (RPKM 16.9), placenta adult (RPKM 16.6) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rfwd3 in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (111270944..111300222, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (113794844..113824122, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase phosphatase regulatory subunit Neighboring gene RIKEN cDNA 9430091E24 gene Neighboring gene golgi apparatus protein 1 Neighboring gene ubiquitin-40S ribosomal protein S27a pseudogene Neighboring gene mixed lineage kinase domain-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Homology

    Clone Names

    • MGC27888

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    MDM2/MDM4 family protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    chromosome breakage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
     
    interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic G1 DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    replication fork processing ISO
    Inferred from Sequence Orthology
    more info
     
    response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    site of DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RFWD3
    Names
    RING finger and WD repeat domain-containing protein 3
    RING finger protein 201
    RING-type E3 ubiquitin transferase RFWD3
    NP_666330.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146218.4NP_666330.2  E3 ubiquitin-protein ligase RFWD3

      See identical proteins and their annotated locations for NP_666330.2

      Status: PROVISIONAL

      Source sequence(s)
      AC163625
      Consensus CDS
      CCDS22672.1
      UniProtKB/Swiss-Prot
      Q8CIK8
      Related
      ENSMUSP00000043780.4, OTTMUSP00000078335, ENSMUST00000038739.4, OTTMUST00000151053
      Conserved Domains (4) summary
      COG2319
      Location:486626
      WD40; WD40 repeat [General function prediction only]
      cd00162
      Location:287334
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      sd00039
      Location:501537
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:451571
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      111270944..111300222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center