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    Aars alanyl-tRNA synthetase [ Mus musculus (house mouse) ]

    Gene ID: 234734, updated on 23-Jun-2021

    Summary

    Official Symbol
    Aarsprovided by MGI
    Official Full Name
    alanyl-tRNA synthetaseprovided by MGI
    Primary source
    MGI:MGI:2384560
    See related
    Ensembl:ENSMUSG00000031960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    sti; Aars1; C76919; AI316495
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 31.7), liver adult (RPKM 27.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Aars in Genome Data Viewer
    Location:
    8; 8 E1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (111759781..111784237)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111027778..111055569)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (113557867..113580770)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene DEAD box helicase 19a Neighboring gene predicted gene, 51551 Neighboring gene DEAD box helicase 19b Neighboring gene microRNA 3473d Neighboring gene exosome component 6 Neighboring gene predicted gene, 38523 Neighboring gene nuclear encoded tRNA glycine 2 (anticodon GCC) Neighboring gene C-type lectin domain family 18, member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC37368

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables Ser-tRNA(Ala) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Ser-tRNA(Ala) hydrolase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables alanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables alanine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alanine-tRNA ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amino acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables amino acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminoacyl-tRNA editing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables aminoacyl-tRNA editing activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables aminoacyl-tRNA editing activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in alanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in alanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within alanyl-tRNA aminoacylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in alanyl-tRNA aminoacylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cytoplasmic translational fidelity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    alanine--tRNA ligase, cytoplasmic
    Names
    alaRS
    alanyl-tRNA synthetase, cytoplasmic
    protein sticky
    NP_666329.2
    XP_006530985.1
    XP_006530987.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146217.4NP_666329.2  alanine--tRNA ligase, cytoplasmic

      See identical proteins and their annotated locations for NP_666329.2

      Status: VALIDATED

      Source sequence(s)
      AA416313, AK085725, AK150227, BM943271
      Consensus CDS
      CCDS40478.1
      UniProtKB/Swiss-Prot
      Q8BGQ7
      UniProtKB/TrEMBL
      Q3UD67
      Related
      ENSMUSP00000034441.8, ENSMUST00000034441.8
      Conserved Domains (1) summary
      PLN02900
      Location:6961
      PLN02900; alanyl-tRNA synthetase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      111759781..111784237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530922.2XP_006530985.1  alanine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006530985.1

      UniProtKB/Swiss-Prot
      Q8BGQ7
      Conserved Domains (1) summary
      PLN02900
      Location:6961
      PLN02900; alanyl-tRNA synthetase
    2. XM_006530924.2XP_006530987.1  alanine--tRNA ligase, cytoplasmic isoform X1

      See identical proteins and their annotated locations for XP_006530987.1

      UniProtKB/Swiss-Prot
      Q8BGQ7
      Conserved Domains (1) summary
      PLN02900
      Location:6961
      PLN02900; alanyl-tRNA synthetase
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