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    Cmtr2 cap methyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 234728, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cmtr2provided by MGI
    Official Full Name
    cap methyltransferase 2provided by MGI
    Primary source
    MGI:MGI:2384580
    See related
    Ensembl:ENSMUSG00000046441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTr2; Ftsjd; Ftsjd1; AU022703; C730036L12Rik
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.1), whole brain E14.5 (RPKM 2.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cmtr2 in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110941977..110951121)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110215346..110224489)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (112741860..112748389)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35543 Neighboring gene calbindin 2 Neighboring gene predicted gene, 39249 Neighboring gene predicted gene, 26832 Neighboring gene HYDIN, axonemal central pair apparatus protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Homology

    Clone Names

    • MGC38131

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cap1 mRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cap2 mRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cap2 mRNA methylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
    Names
    FtsJ methyltransferase domain containing 1
    cap2 2'O-ribose methyltransferase 2
    ftsJ methyltransferase domain-containing protein 1
    NP_666327.2
    XP_006530979.1
    XP_006530980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146215.4NP_666327.2  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

      See identical proteins and their annotated locations for NP_666327.2

      Status: VALIDATED

      Source sequence(s)
      AC163615
      Consensus CDS
      CCDS22662.1
      UniProtKB/Swiss-Prot
      Q8BWQ4
      Related
      ENSMUSP00000060558.5, ENSMUST00000056972.6
      Conserved Domains (1) summary
      pfam01728
      Location:114320
      FtsJ; FtsJ-like methyltransferase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110941977..110951121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530916.4XP_006530979.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530979.1

      UniProtKB/Swiss-Prot
      Q8BWQ4
      Conserved Domains (1) summary
      pfam01728
      Location:114320
      FtsJ; FtsJ-like methyltransferase
    2. XM_006530917.4XP_006530980.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530980.1

      UniProtKB/Swiss-Prot
      Q8BWQ4
      Conserved Domains (1) summary
      pfam01728
      Location:114320
      FtsJ; FtsJ-like methyltransferase
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