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    Cmtr2 cap methyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 234728, updated on 18-Sep-2024

    Summary

    Official Symbol
    Cmtr2provided by MGI
    Official Full Name
    cap methyltransferase 2provided by MGI
    Primary source
    MGI:MGI:2384580
    See related
    Ensembl:ENSMUSG00000046441 AllianceGenome:MGI:2384580
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MTr2; Ftsjd1; C730036L12Rik
    Summary
    Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping; cap1 mRNA methylation; and cap2 mRNA methylation. Predicted to act upstream of or within mRNA processing. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and immune system. Orthologous to human CMTR2 (cap methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 3.1), whole brain E14.5 (RPKM 2.9) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Cmtr2 in Genome Data Viewer
    Location:
    8 D3; 8 57.48 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110941977..110951121)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (110215346..110224489)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35543 Neighboring gene calbindin 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:112741810-112741919 Neighboring gene STARR-seq mESC enhancer starr_22674 Neighboring gene predicted gene, 39249 Neighboring gene predicted gene, 26832 Neighboring gene HYDIN, axonemal central pair apparatus protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

    Clone Names

    • MGC38131

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA (nucleoside-2'-O-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in 7-methylguanosine mRNA capping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in 7-methylguanosine mRNA capping ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in 7-methylguanosine mRNA capping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2
    Names
    FtsJ methyltransferase domain containing 1
    cap2 2'O-ribose methyltransferase 2
    ftsJ methyltransferase domain-containing protein 1
    NP_666327.2
    XP_006530979.1
    XP_006530980.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_146215.4NP_666327.2  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2

      See identical proteins and their annotated locations for NP_666327.2

      Status: VALIDATED

      Source sequence(s)
      AC163615
      Consensus CDS
      CCDS22662.1
      UniProtKB/Swiss-Prot
      Q3TYT6, Q8BWQ4, Q8R3E7
      Related
      ENSMUSP00000060558.5, ENSMUST00000056972.6
      Conserved Domains (1) summary
      pfam01728
      Location:114320
      FtsJ; FtsJ-like methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110941977..110951121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530916.4XP_006530979.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530979.1

      UniProtKB/Swiss-Prot
      Q3TYT6, Q8BWQ4, Q8R3E7
      Conserved Domains (1) summary
      pfam01728
      Location:114320
      FtsJ; FtsJ-like methyltransferase
    2. XM_006530917.4XP_006530980.1  cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 isoform X1

      See identical proteins and their annotated locations for XP_006530980.1

      UniProtKB/Swiss-Prot
      Q3TYT6, Q8BWQ4, Q8R3E7
      Conserved Domains (1) summary
      pfam01728
      Location:114320
      FtsJ; FtsJ-like methyltransferase