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    TRAM1 translocation associated membrane protein 1 [ Homo sapiens (human) ]

    Gene ID: 23471, updated on 5-May-2024

    Summary

    Official Symbol
    TRAM1provided by HGNC
    Official Full Name
    translocation associated membrane protein 1provided by HGNC
    Primary source
    HGNC:HGNC:20568
    See related
    Ensembl:ENSG00000067167 MIM:605190; AllianceGenome:HGNC:20568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRAM; PNAS8; TRAMP
    Summary
    This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 96.1), urinary bladder (RPKM 71.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TRAM1 in Genome Data Viewer
    Location:
    8q13.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (70573218..70608416, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (71003150..71038323, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (71485453..71520651, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375890 Neighboring gene ribosomal protein L13 pseudogene 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:71453867-71454367 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27508 Neighboring gene LACTB2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27510 Neighboring gene lactamase beta 2 Neighboring gene RNA, 7SL, cytoplasmic 19, pseudogene Neighboring gene XK related 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:71660008-71660508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27511 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:71716960-71717817 Neighboring gene uncharacterized LOC124901960

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • PRO1292

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    translocating chain-associated membrane protein 1
    Names
    translocating chain-associating membrane protein
    translocation-associating membrane protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317804.2NP_001304733.1  translocating chain-associated membrane protein 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA740941, AC120194, AK303411, BC032018, BC037738, BQ233660, DB448315
      UniProtKB/TrEMBL
      Q6FHU7
      Conserved Domains (2) summary
      smart00724
      Location:86295
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:1984
      TRAM1; TRAM1-like protein
    2. NM_001317805.2NP_001304734.1  translocating chain-associated membrane protein 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AA740941, AC120194, AK303411, BC032018, BC037738, BQ233660
      Consensus CDS
      CCDS83300.1
      UniProtKB/TrEMBL
      G3XAN4
      Related
      ENSP00000428052.1, ENST00000521425.5
      Conserved Domains (2) summary
      smart00724
      Location:31240
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:129
      TRAM1; TRAM1-like protein
    3. NM_014294.6NP_055109.1  translocating chain-associated membrane protein 1 isoform 1

      See identical proteins and their annotated locations for NP_055109.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AA740941, AC120194, BC037738, BI465346, DB448315
      Consensus CDS
      CCDS6207.1
      UniProtKB/Swiss-Prot
      B4E0K2, Q15629
      UniProtKB/TrEMBL
      Q6FHL3, Q6FHU7
      Related
      ENSP00000262213.2, ENST00000262213.7
      Conserved Domains (2) summary
      smart00724
      Location:117326
      TLC; TRAM, LAG1 and CLN8 homology domains
      pfam08390
      Location:50115
      TRAM1; TRAM1-like protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      70573218..70608416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421636.1XP_047277592.1  translocating chain-associated membrane protein 1 isoform X1

      UniProtKB/TrEMBL
      G3XAN4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      71003150..71038323 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)