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    Nae1 NEDD8 activating enzyme E1 subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 234664, updated on 17-Jul-2018

    Summary

    Official Symbol
    Nae1provided by MGI
    Official Full Name
    NEDD8 activating enzyme E1 subunit 1provided by MGI
    Primary source
    MGI:MGI:2384561
    See related
    Ensembl:ENSMUSG00000031878 Vega:OTTMUSG00000029165
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    59kDa; Appbp1
    Expression
    Broad expression in CNS E18 (RPKM 19.2), CNS E14 (RPKM 18.9) and 21 other tissues See more
    Orthologs

    Genomic context

    See Nae1 in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (104511028..104534655, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (107034928..107058537, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene dynein, cytoplasmic 1 light intermediate chain 2 Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene carbonic anhydrase 7 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Alzheimer's disease, organism-specific biosystem (from KEGG)
      Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimer's disease, conserved biosystem (from KEGG)
      Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
    • Alzheimers Disease, organism-specific biosystem (from WikiPathways)
      Alzheimers Disease, organism-specific biosystemThis pathway displays current genes, proteolytic events and other processes associated with the progression of Alzheimer's disease. This pathway was adapted from KEGG on 10/7/2011. Note: mitochondria...

    General gene information

    Homology

    Clone Names

    • MGC29435, MGC36437, MGC36630

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NEDD8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to NEDD8 activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic DNA replication checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    NEDD8-activating enzyme E1 regulatory subunit
    Names
    APP-BP1
    amyloid beta precursor protein binding protein 1, 59kDa
    amyloid beta precursor protein-binding protein 1, 59 kDa
    amyloid protein-binding protein 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144931.3NP_659180.1  NEDD8-activating enzyme E1 regulatory subunit

      See identical proteins and their annotated locations for NP_659180.1

      Status: VALIDATED

      Source sequence(s)
      AC130543
      Consensus CDS
      CCDS40452.1
      UniProtKB/Swiss-Prot
      Q8VBW6
      UniProtKB/TrEMBL
      Q3UK27
      Related
      ENSMUSP00000034349.9, OTTMUSP00000037203, ENSMUST00000034349.9, OTTMUST00000072328
      Conserved Domains (2) summary
      COG0476
      Location:9193
      ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
      cd01493
      Location:11532
      APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      104511028..104534655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530884.2XP_006530947.1  NEDD8-activating enzyme E1 regulatory subunit isoform X1

      UniProtKB/TrEMBL
      E0CZE0
      Related
      ENSMUSP00000125456.1, OTTMUSP00000037204, ENSMUST00000162466.7, OTTMUST00000072331
      Conserved Domains (2) summary
      COG0476
      Location:9169
      ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
      cd01493
      Location:11508
      APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
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