Format

Send to:

Choose Destination
    • Showing Current items.

    Nae1 NEDD8 activating enzyme E1 subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 234664, updated on 6-Jul-2021

    Summary

    Official Symbol
    Nae1provided by MGI
    Official Full Name
    NEDD8 activating enzyme E1 subunit 1provided by MGI
    Primary source
    MGI:MGI:2384561
    See related
    Ensembl:ENSMUSG00000031878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ap; 59kDa; Appbp1
    Expression
    Broad expression in CNS E18 (RPKM 19.2), CNS E14 (RPKM 18.9) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Nae1 in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105237660..105261269, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104511028..104534656, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (107034928..107058537, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene dynein, cytoplasmic 1 light intermediate chain 2 Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene predicted gene, 22148 Neighboring gene carbonic anhydrase 7 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC29435, MGC36437, MGC36630

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NEDD8 activating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to NEDD8 activating enzyme activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-like modifier activating enzyme activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic DNA replication checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein modification by small protein conjugation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein neddylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    NEDD8-activating enzyme E1 regulatory subunit
    Names
    APP-BP1
    amyloid beta precursor protein binding protein 1, 59kDa
    amyloid beta precursor protein-binding protein 1, 59 kDa
    amyloid protein-binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144931.3NP_659180.1  NEDD8-activating enzyme E1 regulatory subunit

      See identical proteins and their annotated locations for NP_659180.1

      Status: VALIDATED

      Source sequence(s)
      AC130543
      Consensus CDS
      CCDS40452.1
      UniProtKB/Swiss-Prot
      Q8VBW6
      UniProtKB/TrEMBL
      Q3UK27
      Related
      ENSMUSP00000034349.10, ENSMUST00000034349.10
      Conserved Domains (2) summary
      COG0476
      Location:9193
      ThiF; Molybdopterin or thiamine biosynthesis adenylyltransferase [Coenzyme transport and metabolism]
      cd01493
      Location:11532
      APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      105237660..105261269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530884.4XP_006530947.1  NEDD8-activating enzyme E1 regulatory subunit isoform X1

      UniProtKB/TrEMBL
      E0CZE0
      Related
      ENSMUSP00000125456.2, ENSMUST00000162466.8
      Conserved Domains (1) summary
      cd01493
      Location:11508
      APPBP1_RUB; Ubiquitin activating enzyme (E1) subunit APPBP1. APPBP1 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...
    Support Center