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    Cnot1 CCR4-NOT transcription complex, subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 234594, updated on 19-Mar-2019

    Summary

    Official Symbol
    Cnot1provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 1provided by MGI
    Primary source
    MGI:MGI:2442402
    See related
    Ensembl:ENSMUSG00000036550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA815922; D830048B13; 6030411K04Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 29.9), placenta adult (RPKM 21.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cnot1 in Genome Data Viewer
    Location:
    8; 8 D1
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (95719451..95807505, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (98243351..98331366, complement)

    Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene N-myc downstream regulated gene 4 Neighboring gene SET domain containing 6 Neighboring gene ATP synthase subunit epsilon, mitochondrial pseudogene Neighboring gene microRNA 7073 Neighboring gene RIKEN cDNA 4930513N10 gene Neighboring gene Sin3-associated polypeptide 18B Neighboring gene predicted gene, 31805

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7843, MGC189870, MGC189936

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    armadillo repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytoplasmic mRNA processing body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of stem cell population maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    CCR4-NOT core complex IEA
    Inferred from Electronic Annotation
    more info
     
    P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    P-body ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 1
    Names
    CCR4-associated factor 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205226.1NP_001192155.1  CCR4-NOT transcription complex subunit 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site and has an additional in-frame exon in the coding region, compared to variant 1. This results in a longer protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC113951, AC127300
      Consensus CDS
      CCDS85589.1
      UniProtKB/TrEMBL
      A0A1D5RMJ8
      Related
      ENSMUSP00000148807.1, ENSMUST00000211887.1
      Conserved Domains (5) summary
      pfam04054
      Location:19912346
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13821527
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10811305
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:813997
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:498654
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    2. NM_153164.3NP_694804.3  CCR4-NOT transcription complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_694804.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC113951, AC127300
      Consensus CDS
      CCDS57635.1
      UniProtKB/TrEMBL
      B7ZWL1
      Related
      ENSMUSP00000063565.8, ENSMUST00000068452.9
      Conserved Domains (5) summary
      pfam04054
      Location:19932301
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13841529
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10831307
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:815999
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    3. NM_178078.2NP_835179.1  CCR4-NOT transcription complex subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_835179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is longer than isoform 1.
      Source sequence(s)
      AC113951, AC127300
      UniProtKB/Swiss-Prot
      Q6ZQ08
      Conserved Domains (5) summary
      pfam04054
      Location:19932348
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13841529
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10831307
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:815999
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

      Range
      95719451..95807505 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530870.1XP_006530933.1  CCR4-NOT transcription complex subunit 1 isoform X1

      Conserved Domains (5) summary
      pfam04054
      Location:20052360
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13891534
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10881312
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:8151004
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    2. XM_017312735.1XP_017168224.1  CCR4-NOT transcription complex subunit 1 isoform X4

    3. XM_006530871.2XP_006530934.1  CCR4-NOT transcription complex subunit 1 isoform X2

      Conserved Domains (5) summary
      pfam04054
      Location:20042359
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13881533
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10871311
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:8141003
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    4. XM_006530872.2XP_006530935.1  CCR4-NOT transcription complex subunit 1 isoform X3

      Conserved Domains (5) summary
      pfam04054
      Location:20002355
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13841529
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10831307
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:815999
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    5. XM_006530874.2XP_006530937.1  CCR4-NOT transcription complex subunit 1 isoform X5

      See identical proteins and their annotated locations for XP_006530937.1

      UniProtKB/Swiss-Prot
      Q6ZQ08
      Related
      ENSMUSP00000096073.4, ENSMUST00000098473.10
      Conserved Domains (5) summary
      pfam04054
      Location:19982353
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13891534
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10881312
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:8151004
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    RNA

    1. XR_001778430.1 RNA Sequence

    2. XR_001778431.1 RNA Sequence

      Related
      ENSMUST00000213006.1
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