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    Cnot1 CCR4-NOT transcription complex, subunit 1 [ Mus musculus (house mouse) ]

    Gene ID: 234594, updated on 23-Jun-2021

    Summary

    Official Symbol
    Cnot1provided by MGI
    Official Full Name
    CCR4-NOT transcription complex, subunit 1provided by MGI
    Primary source
    MGI:MGI:2442402
    See related
    Ensembl:ENSMUSG00000036550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AA815922; D830048B13; 6030411K04Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 29.9), placenta adult (RPKM 21.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cnot1 in Genome Data Viewer
    Location:
    8; 8 D1
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (96445559..96534741, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95718931..95808113, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (98243351..98331366, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene gem (nuclear organelle) associated protein 8 pseudogene Neighboring gene N-myc downstream regulated gene 4 Neighboring gene predicted gene, 51585 Neighboring gene SET domain containing 6 Neighboring gene predicted gene, 26493 Neighboring gene microRNA 7073 Neighboring gene predicted gene, 26265 Neighboring gene RIKEN cDNA 4930513N10 gene Neighboring gene Sin3-associated polypeptide 18B Neighboring gene predicted gene, 31805

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7843, MGC189870, MGC189936

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables armadillo repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables estrogen receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to poly(A)-specific ribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within gene silencing by RNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene silencing by miRNA ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of intracellular estrogen receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of retinoic acid receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of cytoplasmic mRNA processing body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in trophectodermal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of CCR4-NOT core complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in P-body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 1
    Names
    CCR4-associated factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205226.2NP_001192155.1  CCR4-NOT transcription complex subunit 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113951, AC127300
      Consensus CDS
      CCDS85589.1
      UniProtKB/TrEMBL
      A0A1D5RMJ8
      Related
      ENSMUSP00000148807.2, ENSMUST00000211887.2
      Conserved Domains (5) summary
      pfam04054
      Location:19912346
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13821527
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10811305
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:813997
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:498654
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    2. NM_001372351.1NP_001359280.1  CCR4-NOT transcription complex subunit 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113951, AC127300
      Conserved Domains (2) summary
      COG5103
      Location:8342370
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    3. NM_001372353.1NP_001359282.1  CCR4-NOT transcription complex subunit 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113951, AC127300
      Consensus CDS
      CCDS90442.1
      Related
      ENSMUSP00000096073.5, ENSMUST00000098473.11
      Conserved Domains (2) summary
      COG5103
      Location:8402369
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    4. NM_153164.4NP_694804.3  CCR4-NOT transcription complex subunit 1 isoform 1

      See identical proteins and their annotated locations for NP_694804.3

      Status: VALIDATED

      Source sequence(s)
      AC113951, AC127300
      Consensus CDS
      CCDS57635.1
      UniProtKB/TrEMBL
      B7ZWL1
      Related
      ENSMUSP00000063565.9, ENSMUST00000068452.10
      Conserved Domains (5) summary
      pfam04054
      Location:19932301
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13841529
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10831307
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:815999
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    5. NM_178078.3NP_835179.1  CCR4-NOT transcription complex subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_835179.1

      Status: VALIDATED

      Source sequence(s)
      AC113951, AC127300
      UniProtKB/Swiss-Prot
      Q6ZQ08
      Conserved Domains (5) summary
      pfam04054
      Location:19932348
      Not1; CCR4-Not complex component, Not1
      pfam12842
      Location:13841529
      DUF3819; Domain of unknown function (DUF3819)
      pfam16415
      Location:10831307
      CNOT1_CAF1_bind; CCR4-NOT transcription complex subunit 1 CAF1-binding domain
      pfam16417
      Location:815999
      CNOT1_TTP_bind; CCR4-NOT transcription complex subunit 1 TTP binding domain
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      96445559..96534741 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006530870.2XP_006530933.1  CCR4-NOT transcription complex subunit 1 isoform X1

      Conserved Domains (2) summary
      COG5103
      Location:8402376
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    2. XM_036153965.1XP_036009858.1  CCR4-NOT transcription complex subunit 1 isoform X5

      Conserved Domains (2) summary
      COG5103
      Location:8342363
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    3. XM_036153964.1XP_036009857.1  CCR4-NOT transcription complex subunit 1 isoform X4

      Conserved Domains (2) summary
      COG5103
      Location:8392368
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    4. XM_006530871.3XP_006530934.1  CCR4-NOT transcription complex subunit 1 isoform X2

      Conserved Domains (2) summary
      COG5103
      Location:8392375
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat
    5. XM_006530872.3XP_006530935.1  CCR4-NOT transcription complex subunit 1 isoform X3

      Conserved Domains (2) summary
      COG5103
      Location:8352371
      CDC39; Cell division control protein, negative regulator of transcription [Cell division and chromosome partitioning / Transcription]
      pfam16418
      Location:500656
      CNOT1_HEAT; CCR4-NOT transcription complex subunit 1 HEAT repeat

    RNA

    1. XR_003947260.1 RNA Sequence

    2. XR_001778431.3 RNA Sequence

      Related
      ENSMUST00000213006.2
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