ANGPTL2 angiopoietin like 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANGPTL2provided by HGNC
Official Full Name: angiopoietin like 2provided by HGNC
Primary source: HGNC:HGNC:490
See related: Ensembl:ENSG00000136859 MIM:605001; AllianceGenome:HGNC:490
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARP2; HARP
Summary: Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein with homology to the angiopoietins and may exert a function on endothelial cells through autocrine or paracrine action. [provided by RefSeq, Jul 2008]
Expression: Broad expression in fat (RPKM 35.2), gall bladder (RPKM 19.9) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 9q33.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_03	current	GRCh38.p14 (GCF_000001405.40)	9	NC_000009.12 (127087348..127122635, complement)
RS_2023_03	current	T2T-CHM13v2.0 (GCF_009914755.1)	9	NC_060933.1 (139293792..139329078, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	9	NC_000009.11 (129849627..129884914, complement)

Chromosome 9 - NC_000009.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis.
Title: ANGPTL2 promotes VEGF-A synthesis in human lung cancer and facilitates lymphangiogenesis.
Angiopoietin-like protein 2 deficiency promotes periodontal inflammation and alveolar bone loss.
Title: Angiopoietin-like protein 2 deficiency promotes periodontal inflammation and alveolar bone loss.
Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence.
Title: Angptl2 is a Marker of Cellular Senescence: The Physiological and Pathophysiological Impact of Angptl2-Related Senescence.
Angiopoietin-like 2 is a potential biomarker for diabetic foot patients.
Title: Angiopoietin-like 2 is a potential biomarker for diabetic foot patients.
Vitreous levels of vascular endothelial growth factor, stromal cell-derived factor-1alpha, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy.
Title: Vitreous levels of vascular endothelial growth factor, stromal cell-derived factor-1α, and angiopoietin-like protein 2 in patients with active proliferative diabetic retinopathy.
Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.
Title: Angiopoietin-like protein 2 decreases peritoneal metastasis of ovarian cancer cells by suppressing anoikis resistance.
CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.
Title: CSN5 Promotes Carcinogenesis of Thyroid Carcinoma Cells Through ANGPTL2.
Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.
Title: Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.
Knockdown of ANGPTL2 Protects Renal Tubular Epithelial Cells Against Hypoxia/Reoxygenation-Induced Injury via Suppressing TLR4/NF-kappaB Signaling Pathway and Activating Nrf2/HO-1 Signaling Pathway.
Title: Knockdown of ANGPTL2 Protects Renal Tubular Epithelial Cells Against Hypoxia/Reoxygenation-Induced Injury via Suppressing TLR4/NF-κB Signaling Pathway and Activating Nrf2/HO-1 Signaling Pathway.
Myositis ossificans-like soft tissue aneurysmal bone cyst: a clinical, radiological, and pathological study of seven cases with COL1A1-USP6 fusion and a novel ANGPTL2-USP6 fusion.
Title: Myositis ossificans-like soft tissue aneurysmal bone cyst: a clinical, radiological, and pathological study of seven cases with COL1A1-USP6 fusion and a novel ANGPTL2-USP6 fusion.

Submit: New GeneRIF Correction See all GeneRIFs (73)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with ANGPTL2; predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ANGPTL2_1565 (e-PCR)
- UniSTS:276994

ANGPTL2_v541 (e-PCR)
- UniSTS:276994

ANGPTL2 (e-PCR)
- UniSTS:506134

RH66020 (e-PCR)
- UniSTS:35111

SHGC-146875 (e-PCR)
- UniSTS:175485

RH12756 (e-PCR)
- UniSTS:25279

Homology

Homologs of the ANGPTL2 gene: The ANGPTL2 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 347 organisms have orthologs with human gene ANGPTL2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell signaling	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: angiopoietin-related protein 2

Names: angiopoietin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012098.3 → NP_036230.1 angiopoietin-related protein 2 precursor

See identical proteins and their annotated locations for NP_036230.1

Status: REVIEWED

Source sequence(s)

AK074726, AL356862, AL598400, BC012368

Consensus CDS

CCDS6868.1

UniProtKB/Swiss-Prot

Q8NCH7, Q9UKU9

UniProtKB/TrEMBL

A0A024R868

Related

ENSP00000362524.3, ENST00000373425.8

Conserved Domains (1) summary

cd00087
Location:273 → 487

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...