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    FRAT2 FRAT regulator of WNT signaling pathway 2 [ Homo sapiens (human) ]

    Gene ID: 23401, updated on 17-Jun-2024

    Summary

    Official Symbol
    FRAT2provided by HGNC
    Official Full Name
    FRAT regulator of WNT signaling pathway 2provided by HGNC
    Primary source
    HGNC:HGNC:16048
    See related
    Ensembl:ENSG00000181274 MIM:605006; AllianceGenome:HGNC:16048
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRAT-2
    Summary
    The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]
    Orthologs
    NEW
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    Genomic context

    See FRAT2 in Genome Data Viewer
    Location:
    10q24.1
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97332497..97334729, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98212697..98214929, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99092254..99094486, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12 pseudogene 27 Neighboring gene Sharpr-MPRA regulatory region 7927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3847 Neighboring gene FRAT regulator of WNT signaling pathway 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99093197-99094104 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2675 Neighboring gene uncharacterized LOC105378448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2676 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:99096642-99097160 Neighboring gene ribosomal RNA processing 12 homolog Neighboring gene ribosomal protein L34 pseudogene 20

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC10562

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in canonical Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein export from nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    GSK-3-binding protein FRAT2
    Names
    FRAT2, WNT signaling pathway regulator
    frequently rearranged in advanced T-cell lymphomas 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012083.3NP_036215.1  GSK-3-binding protein FRAT2

      See identical proteins and their annotated locations for NP_036215.1

      Status: REVIEWED

      Source sequence(s)
      AB045118, AL355490, BU675503, DR006612
      Consensus CDS
      CCDS7456.1
      UniProtKB/Swiss-Prot
      O75474, Q5JTI0, Q8WUL9, Q9BYG2
      UniProtKB/TrEMBL
      Q53XP8
      Related
      ENSP00000360058.2, ENST00000371019.4
      Conserved Domains (1) summary
      pfam05350
      Location:1211
      GSK-3_bind; Glycogen synthase kinase-3 binding

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97332497..97334729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98212697..98214929 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)