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    Tufm Tu translation elongation factor, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 233870, updated on 5-Sep-2021

    Summary

    Official Symbol
    Tufmprovided by MGI
    Official Full Name
    Tu translation elongation factor, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1923686
    See related
    Ensembl:ENSMUSG00000073838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EFTU; C76308; C76389; EF-TuMT; 2300002G02Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 104.1), heart adult (RPKM 88.3) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tufm in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126086445..126089903)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126487271..126490731)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (133630869..133634245)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene SH2B adaptor protein 1 Neighboring gene predicted gene, 46001 Neighboring gene ataxin 2-like Neighboring gene RIKEN cDNA 4930456A14 gene Neighboring gene eukaryotic translation initiation factor 3, subunit C Neighboring gene predicted gene, 24596

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within translation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in translational elongation ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    elongation factor Tu, mitochondrial

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163713.1NP_001157185.1  elongation factor Tu, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001157185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment that results in a frameshift compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK152858, BC060959, BU699735, BY246546
      Consensus CDS
      CCDS52398.1
      UniProtKB/Swiss-Prot
      Q8BFR5
      Related
      ENSMUSP00000102000.4, ENSMUST00000106392.10
      Conserved Domains (3) summary
      cd01884
      Location:56250
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      pfam00009
      Location:55248
      GTP_EFTU; Elongation factor Tu GTP binding domain
      cd03697
      Location:258344
      EFTU_II; Domain II of elongation factor Tu
    2. NM_172745.3NP_766333.1  elongation factor Tu, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_766333.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK152858, BC060959, BY246546
      Consensus CDS
      CCDS21830.1
      UniProtKB/Swiss-Prot
      Q8BFR5
      Related
      ENSMUSP00000095656.5, ENSMUST00000098048.6
      Conserved Domains (4) summary
      cd01884
      Location:56250
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      PRK00049
      Location:47439
      PRK00049; elongation factor Tu; Reviewed
      cd03697
      Location:258344
      EFTU_II; Domain II of elongation factor Tu
      cd03706
      Location:347439
      mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126086445..126089903
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507719.5XP_006507782.1  elongation factor Tu, mitochondrial isoform X1

      Conserved Domains (1) summary
      PRK00049
      Location:47411
      PRK00049; elongation factor Tu; Reviewed
    2. XM_036153012.1XP_036008905.1  elongation factor Tu, mitochondrial isoform X2

      Conserved Domains (1) summary
      PRK00049
      Location:1303
      PRK00049; elongation factor Tu; Reviewed
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