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    Tufm Tu translation elongation factor, mitochondrial [ Mus musculus (house mouse) ]

    Gene ID: 233870, updated on 9-Sep-2018

    Summary

    Official Symbol
    Tufmprovided by MGI
    Official Full Name
    Tu translation elongation factor, mitochondrialprovided by MGI
    Primary source
    MGI:MGI:1923686
    See related
    Ensembl:ENSMUSG00000073838 Vega:OTTMUSG00000058216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EFTU; C76308; C76389; EF-TuMT; 2300002G02Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 104.1), heart adult (RPKM 88.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tufm in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (126487354..126490731)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (133630869..133634245)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene SH2B adaptor protein 1 Neighboring gene predicted gene, 46001 Neighboring gene ataxin 2-like Neighboring gene RIKEN cDNA 4930456A14 gene Neighboring gene eukaryotic translation initiation factor 3, subunit C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation elongation factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    mitochondrial translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translation IEA
    Inferred from Electronic Annotation
    more info
     
    translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    translational elongation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane HDA PubMed 
    mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion HDA PubMed 
    mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    elongation factor Tu, mitochondrial

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163713.1NP_001157185.1  elongation factor Tu, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001157185.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes an alternate segment that results in a frameshift compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AK152858, BC060959, BU699735, BY246546
      Consensus CDS
      CCDS52398.1
      UniProtKB/Swiss-Prot
      Q8BFR5
      Related
      ENSMUSP00000102000.3, OTTMUSP00000074557, ENSMUST00000106392.9, OTTMUST00000142970
      Conserved Domains (3) summary
      cd01884
      Location:56250
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      pfam00009
      Location:55248
      GTP_EFTU; Elongation factor Tu GTP binding domain
      cd03697
      Location:258344
      EFTU_II; Domain II of elongation factor Tu
    2. NM_172745.3NP_766333.1  elongation factor Tu, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_766333.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK152858, BC060959, BY246546
      Consensus CDS
      CCDS21830.1
      UniProtKB/Swiss-Prot
      Q8BFR5
      Related
      ENSMUSP00000095656.4, OTTMUSP00000074556, ENSMUST00000098048.5, OTTMUST00000142968
      Conserved Domains (4) summary
      cd01884
      Location:56250
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      PRK00049
      Location:47439
      PRK00049; elongation factor Tu; Reviewed
      cd03697
      Location:258344
      EFTU_II; Domain II of elongation factor Tu
      cd03706
      Location:347439
      mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      126487354..126490731
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507719.3XP_006507782.1  elongation factor Tu, mitochondrial isoform X1

      Conserved Domains (4) summary
      cd01884
      Location:56250
      EF_Tu; Elongation Factor Tu (EF-Tu) GTP-binding proteins
      PRK00049
      Location:47411
      PRK00049; elongation factor Tu; Reviewed
      cd03706
      Location:319411
      mtEFTU_III; Domain III of mitochondrial EF-TU (mtEF-TU)
      cl02787
      Location:258316
      Translation_Factor_II_like; Domain II of Elongation factor Tu (EF-Tu)-like proteins
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