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    Smg1 SMG1 nonsense mediated mRNA decay associated PI3K related kinase [ Mus musculus (house mouse) ]

    Gene ID: 233789, updated on 5-Sep-2021

    Summary

    Official Symbol
    Smg1provided by MGI
    Official Full Name
    SMG1 nonsense mediated mRNA decay associated PI3K related kinaseprovided by MGI
    Primary source
    MGI:MGI:1919742
    See related
    Ensembl:ENSMUSG00000030655
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0421; 2610207I05Rik; 5430435M13Rik; C130002K18Rik
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 16.3), thymus adult (RPKM 14.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Smg1 in Genome Data Viewer
    Location:
    7; 7 F1
    Exon count:
    64
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (117730531..117843026, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (118131308..118244437, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (125274826..125387151, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S15A Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 Neighboring gene predicted gene, 25683 Neighboring gene predicted gene, 40454 Neighboring gene RIKEN cDNA 4930583K01 gene Neighboring gene predicted gene, 34999 Neighboring gene predicted gene, 23229

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (2) 
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase C activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of TORC1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of TORC2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase SMG1
    Names
    PI-3-kinase-related kinase SMG-1
    SMG-1
    SMG1 homolog, phosphatidylinositol 3-kinase-related kinase
    phosphatidylinositol 3-kinase-related protein kinase
    NP_001026984.1
    XP_006507740.1
    XP_006507741.1
    XP_030098366.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031814.1NP_001026984.1  serine/threonine-protein kinase SMG1

      See identical proteins and their annotated locations for NP_001026984.1

      Status: PROVISIONAL

      Source sequence(s)
      AC131788, AC132432
      Consensus CDS
      CCDS40102.1
      UniProtKB/Swiss-Prot
      Q8BKX6
      Related
      ENSMUSP00000032891.9, ENSMUST00000032891.15
      Conserved Domains (3) summary
      cd05170
      Location:21192424
      PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
      pfam02260
      Location:36283657
      FATC; FATC domain
      pfam15785
      Location:6291240
      SMG1; Serine/threonine-protein kinase smg-1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      117730531..117843026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507677.4XP_006507740.1  serine/threonine-protein kinase SMG1 isoform X1

      Conserved Domains (4) summary
      cd05170
      Location:21182423
      PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
      pfam02260
      Location:36273656
      FATC; FATC domain
      pfam15785
      Location:6281239
      SMG1; Serine/threonine-protein kinase smg-1
      pfam17229
      Location:30138
      DUF5303; Region of unknown function (DUF5303)
    2. XM_006507678.3XP_006507741.1  serine/threonine-protein kinase SMG1 isoform X2

      Conserved Domains (4) summary
      cd05170
      Location:20952400
      PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
      pfam02260
      Location:36043633
      FATC; FATC domain
      pfam15785
      Location:6051216
      SMG1; Serine/threonine-protein kinase smg-1
      pfam17229
      Location:6114
      DUF5303; Region of unknown function (DUF5303)
    3. XM_030242506.1XP_030098366.1  serine/threonine-protein kinase SMG1 isoform X3

      Conserved Domains (4) summary
      cd05170
      Location:20942399
      PIKKc_SMG1; Catalytic domain of Suppressor of Morphogenetic effect on Genitalia-1
      pfam02260
      Location:36033632
      FATC; FATC domain
      pfam15785
      Location:6041215
      SMG1; Serine/threonine-protein kinase smg-1
      pfam17229
      Location:6114
      DUF5303; Region of unknown function (DUF5303)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_177180.2: Suppressed sequence

      Description
      NM_177180.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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