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    RRP8 ribosomal RNA processing 8 [ Homo sapiens (human) ]

    Gene ID: 23378, updated on 25-May-2024

    Summary

    Official Symbol
    RRP8provided by HGNC
    Official Full Name
    ribosomal RNA processing 8provided by HGNC
    Primary source
    HGNC:HGNC:29030
    See related
    Ensembl:ENSG00000132275 MIM:615818; AllianceGenome:HGNC:29030
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NML; KIAA0409
    Summary
    Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of chromatin silencing complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen (RPKM 2.0), lymph node (RPKM 1.9) and 25 other tissues See more
    Orthologs
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    Genomic context

    See RRP8 in Genome Data Viewer
    Location:
    11p15.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (6595072..6603616, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (6653543..6662088, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (6616302..6624846, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene voltage dependent anion channel 1 pseudogene Neighboring gene dynein heavy chain domain 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6589123-6589980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6592335-6592842 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6607422-6608410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:6608411-6609399 Neighboring gene Sharpr-MPRA regulatory region 2811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:6624079-6624620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3104 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4345 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4347 Neighboring gene Sharpr-MPRA regulatory region 730 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:6632062-6632650 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:6632651-6633238 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3107 Neighboring gene TATA-box binding protein associated factor 10 Neighboring gene integrin linked kinase Neighboring gene tripeptidyl peptidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0409

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables S-adenosylmethionine-dependent methyltransferase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables methylated histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of chromatin silencing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of chromatin silencing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    part_of eNoSc complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    part_of rDNA heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ribosomal RNA-processing protein 8
    Names
    RRP8 methyltransferase homolog
    cerebral protein 1
    nucleomethylin
    ribosomal RNA processing 8, methyltransferase, homolog
    NP_056139.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015324.4NP_056139.1  ribosomal RNA-processing protein 8

      See identical proteins and their annotated locations for NP_056139.1

      Status: VALIDATED

      Source sequence(s)
      AB007869, AC009796, BC001071, BX417992, R51624
      Consensus CDS
      CCDS31411.1
      UniProtKB/Swiss-Prot
      O43159, Q7KZ78, Q9BVM6
      Related
      ENSP00000254605.6, ENST00000254605.11
      Conserved Domains (1) summary
      pfam05148
      Location:242456
      Methyltransf_8; Hypothetical methyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      6595072..6603616 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      6653543..6662088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)