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    Ipo7 importin 7 [ Mus musculus (house mouse) ]

    Gene ID: 233726, updated on 12-Aug-2018

    Summary

    Official Symbol
    Ipo7provided by MGI
    Official Full Name
    importin 7provided by MGI
    Primary source
    MGI:MGI:2152414
    See related
    Ensembl:ENSMUSG00000066232 Vega:OTTMUSG00000060142
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Imp7; Ranbp7; C330016G14; A330055O14Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 27.1), placenta adult (RPKM 21.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Ipo7 in Genome Data Viewer
    Location:
    7; 7 E3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (110018248..110056609)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (117161939..117198628)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene transmembrane protein 41B Neighboring gene RIKEN cDNA 1600010M07 gene Neighboring gene small nucleolar RNA, H/ACA box 23 Neighboring gene zinc finger protein 143 Neighboring gene WEE 1 homolog 1 (S. pombe)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • PluriNetWork, organism-specific biosystem (from WikiPathways)
      PluriNetWork, organism-specific biosystemThe aim of the PluriNetWork is to give an overview of specific mechanisms associated with pluripotency in mouse. Each node represents a gene and its corresponding protein product. As stated, we inten...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Ran GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    SMAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    importin-7
    Names
    RAN binding protein 7

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362172.1NP_001349101.1  importin-7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC140235
      Conserved Domains (1) summary
      cl27876
      Location:15996
      Cse1; Cse1
    2. NM_181517.4NP_852658.2  importin-7 isoform 1

      See identical proteins and their annotated locations for NP_852658.2

      Status: VALIDATED

      Source sequence(s)
      AC121995, AC140235
      Consensus CDS
      CCDS40085.1
      UniProtKB/Swiss-Prot
      Q9EPL8
      Related
      ENSMUSP00000081782.3, OTTMUSP00000076614, ENSMUST00000084731.4
      Conserved Domains (2) summary
      COG5656
      Location:15997
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
      pfam03810
      Location:22101
      IBN_N; Importin-beta N-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      110018248..110056609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006507657.3XP_006507720.1  importin-7 isoform X1

      Conserved Domains (1) summary
      cl27876
      Location:15996
      Cse1; Cse1
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